医学院
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| 导师代码： |
21640
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| 导师姓名： |
卢元珺
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| 性 别： |
女 |
| 特 称： |
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| 职 称： |
助理研究员
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| 学 位： |
哲学博士学位
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| 属 性： |
专职 |
| 电子邮件： |
yjlu@uestc.edu.cn
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| 学术经历：
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博士，香港大学
硕士，中南大学
本科，中南大学
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| 个人简介：
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卢元珺，理学博士，副研究员，硕士生导师，先后于中南大学获得学士与硕士学位，并于香港大学取得哲学博士学位。专注于肝癌耐药的表观遗传调控机制研究以及重要活性成分的抗肿瘤药力学研究。主持国家自然科学基金青年项目1项，四川省科技厅港澳台科技创新合作项目1项，入选2024年度成都市“蓉漂计划”创新青年人才。近五年在Molecular Cancer, Drug Resistance Updates, Journal of Experimental & Clinical Cancer Research, Journal of Advanced Research 等双一区国际期刊发表论文16篇。参编《基礎與臨床中藥毒理學》和《Macrophage Activation-Biology and Disease》。
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| 科研项目：
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1. 国家自然科学基金——青年科学基金项目（C类）（2026.01—2028.12），30万，主持
2. 四川省科技厅港澳台科技创新合作项目（2024.01-2025.12）, 20万，主持
3. 四川省肿瘤医院优秀青年基金（2024.01-2025.12），10万，主持
3. 四川省肿瘤医院引进人才配套经费，100万，主持
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| 研究成果：
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1. Yuanjun Lu, Ya Wu, Xiaoyu Xu, Yibin Feng, Ning Wang*. Cancer-associated fibroblasts: central players in cancer hallmarks and therapeutic resistance[J]. Cell Communication and Signaling, 2025, 23(1): 534.
2. Yuanjun Lu, Shuoshuo Ma, Yau-Tuen Chan, Ya Wu, Yibin Feng, Ning Wang*. Epigenetic orchestration of cancer-immune dynamics: mechanisms, technologies, and clinical advancements [J]. Journal of Advanced Research, 2025.
3. Yau-Tuen Chan, Junyu Wu, Yuanjun Lu, Qiucheng Li, Zixin Feng, Lin Xu, Hongchao Yuan, Tingyuan Xing, Cheng Zhang, Hor-Yue Tan, Yibin Feng, Ning Wang*. Loss of LncRNA LINC01056 leads to sorafenib resistance in HCC [J]. Molecular cancer, 2024, 23(1): 74.
4. Junyu Wu, Hor-Yue Tan, Yau-Tuen Chan, Yuanjun Lu, Zixin Feng, Hongchao Yuan, Cheng Zhang, Yibin Feng, Ning Wang*. PARD3 drives tumorigenesis through activating Sonic Hedgehog signalling in tumour-initiating cells in liver cancer[J]. Journal of Experimental & Clinical Cancer Research, 2024, 43(1): 42.
5. Yuanjun Lu, Yau-Tuen Chan, Junyu Wu, Zixin Feng, Hongchao Yuan, Qiucheng Li, Tingyuan Xing, Lin Xu, Cheng Zhang, Hor-Yue Tan, Terence Kin-Wah Lee, Yibin Feng, Ning Wang*. CRISPR/Cas9 screens unravel miR-3689a-3p regulating sorafenib resistance in hepatocellular carcinoma via suppressing CCS/SOD1-dependent mitochondrial oxidative stress[J]. Drug Resistance Updates, 2023, 71: 101015.
6. Yuanjun Lu#, Yazhou Liu#, Junjie Lan, Yau-Tuen Chan, Zixin Feng, Lan Huang, Ning Wang*, Weidong Pan*, Yibin Feng*. Thioredoxin-interacting protein-activated intracellular potassium deprivation mediates the anti-tumour effect of a novel histone acetylation inhibitor HL23, a fangchinoline derivative, in human hepatocellular carcinoma[J]. Journal of Advanced Research, 2023, 51: 181-196.
7. Yuanjun Lu, Yau-Tuen Chan, Hor-Yue Tan, Cheng Zhang, Wei Guo, Yu Xu, Rakesh Sharma, Zhe-Sheng Chen, Yi-Chao Zheng, Ning Wang*, Yibin Feng*. Epigenetic regulation of ferroptosis via ETS1/miR-23a-3p/ACSL4 axis mediates sorafenib resistance in human hepatocellular carcinoma[J]. Journal of Experimental & Clinical Cancer Research, 2022, 41(1): 1-17.
8. Yau-Tuen Chan, Yuanjun Lu, Junyu Wu, Cheng Zhang, Hor-Yue Tan, Zhaoxiang Bian, Ning Wang*, Yibin Feng*. CRISPR-Cas9 library screening approach for anti-cancer drug discovery: overview and perspectives[J]. Theranostics, 2022, 12(7): 3329.
9. Ning Wang, Hor-Yue Tan, Yuanjun Lu, Yau-Tuen Chan, Di Wang, Wei Guo, Yu Xu, Cheng Zhang, Feiyu Chen, Guoyi Tang, Yibin Feng*. PIWIL1 governs the crosstalk of cancer cell metabolism and immunosuppressive microenvironment in hepatocellular carcinoma[J]. Signal Transduction and Targeted Therapy, 2021, 6(1): 86.
10. Yuanjun Lu, Yau-Tuen Chan, Hor-Yue Tan, Sha Li, Ning Wang*, Yibin Feng*. Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy[J]. Molecular cancer, 2020, 19: 1-16.
11. Yuanjun Lu, Hor-Yue Tan, Ning Wang*, Yibin Feng*. Polarization of Tumor-Associated Macrophages by Chinese Medicine Intervention: Mechanisms and Applications[M]//Macrophage Activation-Biology and Disease. IntechOpen, 2019.
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| 专业研究方向：
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| 专业名称 |
研究领域/方向 |
招生类别 |
| 071000生物学 |
04细胞生物学 |
硕士学术学位 |
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