医学院
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导师代码: |
21411
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导师姓名: |
田利民
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性 别: |
男 |
特 称: |
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职 称: |
研究员
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学 位: |
医学博士学位
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属 性: |
专职 |
电子邮件: |
1072027801@qq.com
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学术经历:
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1994.09—1999.06 兰州大学临床医学,获学士学位;
2002.09—2005.06 兰州大学内分泌与代谢病专业,获硕士学位;
2007.09—2010.06 山东大学内分泌与代谢病专业,获博士学位;
2011.11—2012.11 德国柏林Deutsche Gesellschaft für Internationale Zusammenarbeit(GIZ) GmbH 留学1年。
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个人简介:
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田利民,博士,教授,主任医师,博士研究生导师,享受国务院政府特殊津贴专家。长期从事内分泌与代谢性疾病临床、科研和教学工作。现任电子科技大学附属医院,四川省人民医院大内科主任,内分泌科主任,四川省老年医学中心主任,老年内分泌科主任。兼任国家代谢性疾病临床医学研究中心分中心主任,中国医师协会内分泌代谢科医师分会副会长,中华医学会内分泌学分会委员,中华医学会糖尿病学会委员,中华预防医学会甲状腺专委会常委,中国老年医学会内分泌学分会常委,四川省医学会糖尿病学会副主任委员,四川省医促会老年医学会主任委员等。主持国家重点研发项目课题1项,国家自然科学基金项目5项,省科技重大专项等科研项目共10余项。获省部级科技进步二等奖以上奖项5项。以第一作者或通讯作者在《Hepatology》、《Thyroid》、《JCEM》等专业期刊发表论文80余篇。
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科研项目:
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代表性科研项目:
1. 国家自然科学基金,肠道菌群代谢物甘氨脱氧胆酸(GDCA)调控线粒体氧化应激影响亚临床甲减认知功能的作用及机制研究,项目编号82470829,2025.1-2028.12,49万元,主持;
2. 国家自然科学基金,TSH通过cAMP/PKA/CREB上调ARRDC2促心肌肥厚的机制研究,项目编号82060152 ,2021年01月至2024年12月,33万元,主持;
3. 国家自然科学基金,TRAb对心肌肥厚的影响及其机制研究,项目编号81760144,2018年01月至2021年12月,34万元,主持;
4. 国家自然科学基金,促甲状腺激素(TSH)对心脏舒缩功能影响的研究,项目编号80360125 ,2013年12月至2017年12月,49万元,主持;
5. 国家自然科学基金,促甲状腺激素(TSH)在动脉粥样硬化中的作用及机制,项目编号81360125,2012年01月至2015年12月,53万元,主持;
6. 国家重点研发计划,糖尿病防控适宜技术及管理平台的建立和示范应用研究,项目编号2018YFC1311502 ,2018年08月至2020年12月, 290万元,主持;
7. 甘肃省重点研发计划,植物外泌体在糖尿病及其并发症治疗中的应用研究,项目编号24YFFA032,2025年1月-2027年12月,20万元,主持;
8. 甘肃肃科技重大专项,1型糖尿病管理平台和标准化分级诊疗示范应用,项目编号项目编号22ZD6FA033 ,2022年08月-2025年12月,150万元,主持。
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研究成果:
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代表性论著:
1. Inhibiting sEH suppresses NF-κB p65 signaling and reduces CXCL10 expression as a potential therapeutic target in HT. Journal of Clinical Endocrinology and Metabolism. 2024 Mar 13:dgae163.中科院2区Top,影响因子6.134分;
2. Structural and Functional Alterations of Hippocampal Subfields in Patients with Adult-onset Primary Hypothyroidism. Journal of Clinical Endocrinology and Metabolism. 2024 Feb 7:dgae070.中科院2区Top,影响因子6.134分;
3. Alterations in gray matter morphology and functional connectivity in adult patients with newly diagnosed, untreated hypothyroidism. Thyroid. 2023 Jul;33(7):791-803 中科院1区Top,影响因子6.506分;
4. Plasma Metabolomics Reveals Systemic Metabolic Alterations of Subclinical and Clinical Hypothyroidism. Journal of Clinical Endocrinology and Metabolism.2022 Oct 1;dgac555.中科院2区Top,影响因子6.134分;
5. A novel role for thyroid-stimulating hormone: up-regulation of hepatic 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase expression through the cyclic adenosine monophosphate/protein kinase A/cyclic adenosine monophosphate-responsive element binding protein pathway. Hepatology.2010 Oct;52(4):1401-9.中科院1区,影响因子10.885分;
6. Development and external validation of a machine learning model to predict diabetic nephropathy in T1DM patients in the real-world. Acta Diabetologica.2024 Nov 11.doi: 10.1007/s00592-024-02404-z;
7. Association Between Dietary Tryptophan Intake and Bone Health: A Cross Sectional Study. Calcified Tissue International. 2024Dec 14;116(1):6. doi: 10.1007/s00223-024-01329-7;
8. Prevalence and Risk Factors of Cardiovascular Autonomic Neuropathy in Individuals with Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis.Reviews in Cardiovascular Medicine.2024 Jul 3;25(7):244.doi: 10.31083/j.rcm2507244;
9. Effect of glycemic control on cognitive function in patients with type 1 diabetes mellitus: a systematic review and meta-analysis.SYSTEMATIC REVIEWS.2024 Jan 2;13(1):10.doi: 10.1186/s13643-023-02433-9;
10. Thyroid hormone levels in patients with bipolar disorder:a systematic review and meta-analysis. BMC Endocrine Disorders.2024 Nov 18;24(1):248;
11. Development and external validation of a machine learning model to predict diabetic nephropathy in T1DM patients in the real-world. Acta Diabetologica.2024 Nov 11.doi: 10.1007/s00592-024-02404-z;
12. AssociationBetween Dietary Tryptophan Intake and Bone Health: A Cross Sectional Study. Calcified Tissue International. 2024Dec 14;116(1):6. doi: 10.1007/s00223-024-01329-7;
13. Prevalence and Risk Factors of Cardiovascular Autonomic Neuropathy in Individuals with Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis.Reviews in Cardiovascular Medicine.2024 Jul 3;25(7):244.doi: 10.31083/j.rcm2507244;
14. Effect of glycemic control on cognitive function in patients with type 1 diabetes mellitus: a systematic review and meta-analysis.SYSTEMATIC REVIEWS.2024 Jan 2;13(1):10.doi: 10.1186/s13643-023-02433-9.;
15. Thyroid hormone levels in patients with bipolar disorder:a systematic review and meta-analysis. BMC Endocrine Disorders.2024 Nov 18;24(1):248;
16. FNDC5/irisin ameliorates bone loss of type 1 diabetes by suppressing endoplasmic reticulum stress-mediated ferroptosis. Journal of Orthopaedic Surgery and Research. 2024 Mar 30;19(1):205.;
17. Impaired Sensitivity to Thyroid Hormones is Associated with the Risk of Diabetic Nephropathy in Euthyroid Patients with Type 1 Diabetes Mellitus. Diabetes Metab Syndr Obes. 2024 Feb 8:17:611-618.;
18. Effect of glycemic control on cognitive function in patients with type 1 diabetes mellitus: a systematic review and meta-analysis. Systematic Reviews. 2024 Jan 2;13(1):10.;
19. Lipidomics analysis of impaired glucose tolerance and type 2 diabetes mellitus in overweight or obese elderly adults. Endocrine Connections. 2023 Nov 15;12(12):e230212.;
20. Effect of thyroid-stimulating hormone suppression therapy on cardiac structure and function in patients with differentiated thyroid cancer after thyroidectomy: a systematic review and meta-analysis. Endocrine Practice. 2023 Nov 23:S1530-891X(23)00757-7.;
21. DAP1 regulates osteoblast autophagy via the ATG16L1-LC3 axis in Graves' disease-induced osteoporosis. Journal of Orthopaedic Surgery And Research. 2023 Sep 21;18(1):711.;
22. Long-term outcomes in lean and non-lean NAFLD patients: a systematic review and meta-analysis. Endocrine. 2023 May 30.;
23. Effect of thyroid dysfunction on N-terminal pro-B-type natriuretic peptide levels: A systematic review and meta-analysis.Frontiers In Endocrinology.2023 Jan 26:14:1083171.;
24. The effectiveness and Safety of Thyroid Hormone Therapy in Patients with Dilated Cardiomyopathy: A Systematic Review and Meta-Analysis of RCTs. American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions.2022 Nov;22(6):647-656.;
25. Identification of Serum Exosome-Derived circRNA-miRNA-TF-mRNA Regulatory Network in Postmenopausal Osteoporosis Using Bioinformatics Analysis and Validation in Peripheral Blood-Derived Mononuclear Cells.Frontiers In Endocrinology.2022 Jun 9:13:899503.;
26. An Update on the Economic Burden of Type 2 Diabetes Mellitus in China. Expert Review of Pharmacoeconomics & Outcomes Research.2022, 22(4): 617-625.;
27. Reporting and Methodological Quality of Systematic Reviews of DPP-4 Inhibitors for Patients with Type 2 Diabetes Mellitus: An Evidence-Based Mapping. Acta Diabetologica.2022 Dec;59(12):1539-1549.;
28. The Effectiveness of Thyroid Hormone Replacement Therapy on Heart Failure and Low-Triiodothyronine Syndrome: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials. Endocrine Practice: Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.2022 Nov;28(11):1178-1186.;
29. Decision models in type 2 diabetes mellitus: A systematic review. Acta Diabetologica. 2021; 58(11):1451-1469.;
32. The Change of Left Ventricular Function in Rats with Subclinical Hypothyroid and the Effects of Thyroxine Replacement. International Journal of Endocrinology.2018,86: 1-10.;
33. Appraisal of clinical practice guidelines on the management of hypothyroidism in pregnancy using the Appraisal of Guidelines for Research and Evaluation II instrument.Endocrine.2018,60(1): 1535-1546.;
34. Adipokine expression and endothelial function in subclinical hypothyroidism rats. Endocrine Connections.2018,7(2):295-304.;
35. Adult serum 25(OH)D3 in Gansu province, northwest China: a cross-sectional study. Asia Pac J Clin Nutr.2018,27(4):832-839.;
36. Robotic Versus Laparoscopic Roux-en-Y Gastric Bypass for Morbid Obesity: a Systematic Review and Meta-Analysis.Obesity Surgery.2018, 28(11): 3691-3700.;
37. The Change of Left Ventricular Function in Rats with Subclinical Hypothyroid and the Effects of Thyroxine Replacement.International Journal of Endocrinology.2018 Mar 4:2018:8682765.;
38. Relationship between Subclinical Thyroid Dysfunction and the Risk of Cardiovascular Outcomes: A Systematic Review. International Journal of Endocrinology.2017,10:1-15.;
39. Methodological Quality Assessment of Meta-Analyses of Hyperthyroidism Treatment. hormone and metabolic research.2017,50(1).;
科研获奖:
1. 2015年《抗氧化物质对糖尿病状态下血管及肾脏功能影响的系列研究》 获省科技进步一等奖;
2. 2013年《东乡、回、汉三民族2型糖尿病若干易感基因的研究》获省科技进步二等奖;
3. 2017年《糖尿病肝窦功能障碍介导的脂肪肝的病理机制及干预策略研究》获省科技进步二等奖;
4. 2018年《促甲状腺激素(TSH)对心血管系统的作用及机制研究》获省科技进步二等奖;
5. 2021年《2型糖尿病危险因素的系列研究》获省科技进步二等奖;
6. 2024年《认知情绪功能异常的早期诊断关键神经影像生物标记筛选及应用》获省科技进步二等奖
软件著作:
1. T1DM-智慧糖控平台,软著登字第12334359号,2023.09.30
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专业研究方向:
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专业名称 |
研究领域/方向 |
招生类别 |
100200临床医学 |
01内科学 |
博士学术学位 |
100200临床医学 |
01内科学 |
硕士学术学位 |
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