医学院
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| 导师代码： |
21216
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| 导师姓名： |
石明松
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| 性 别： |
男 |
| 特 称： |
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| 职 称： |
助理研究员
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| 学 位： |
理学博士学位
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| 属 性： |
专职 |
| 电子邮件： |
therotyonth@163.com
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| 学术经历：
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2023.09-至今 电子科技大学医学院附属绵阳医院 副研究员
2023.01-2023.08 电子科技大学医学院附属绵阳医院 助理研究员
2019.07-2022.12 四川大学华西医院 博士后 助理研究员 合作导师：陈俐娟教授
2016.09-2019.07 四川大学化学学院 博士研究生 导师：徐定国教授
2013.09-2016.07 四川大学化学学院 硕士研究生 导师：徐定国教授
2009.09-2013.07 西华师范大学化学化工学院 大学本科
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| 个人简介：
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石明松，副研究员，博士，博士后。研究方向为计算生物化学和小分子靶向放射性药物。已发表SCI论文40余篇，其中第一作者或通讯作者（含共同）18篇，授权专利2项。任Traditional Medicine Research (编委)，武汉大学学报(理学版) (青年通讯编委)，化学研究(青年编委)，四川省生物信息学会青年委员会(副主任委员)，四川省预防医学会核应急医学干预与管理分会（委员）和四川省生物信息学学会精准医学分会（委员）。主持国家自然科学基金、四川省自然科学基金等科研项目共10项。
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| 科研项目：
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10. 绵阳市卫生健康委，补助科研项目，202301，2024-01至2025-12，1.35万，在研，主持
9. 绵阳市中心医院，引进经费，2023RCYJ-003，2024-01至2025-12，60万，在研，主持
8. 绵阳市中心医院，孵化课题，2023FH001，2024-01至2026-12，5万，在研，主持
7. 秦药特色资源研究开发重点实验室，开放课题，KF202332，2023-06至2025-05，5万，在研，主持
6. 国家卫生健康委员会核技术医学转化重点实验室，开放课题，2023-01至2025-12，17万，在研，主持
5. 国家自然科学基金，青年科学基金，222030056，2023-01至2025-12，30万，在研，主持
4. 护理学四川省重点实验室，开放课题，HLKF2023(F)-4，2023-01至2024-12，1万，在研，主持
3. 光合基金，B类课题，ghfund202302022385，2023-04至2024-04，8万(等值)，结题(优秀课题)，主持
2. 四川省自然科学基金，青年科学基金，2022NSFSC1467，10万元，结题，主持
1. 四川大学华西医院，专职博士后研发基金，2021HXBH017，15万元，结题，主持
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| 研究成果：
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(18) Mei Yutong, Zhang Hui, Jiang Yu, Gu Yujia, Deng Jianglai, Yang Dan, Jing Linhai*, Shi Mingsong*, Modular access to diarylmethyl sulfonamides via visible light-promoted cross-coupling reactions, Chemical Communications, 2024, 10.1039/D4CC02571G
(17) Shi Mingsong#, Zheng Xueting#, Zhou Yan, Yin Yuan, Lu Zhou, Zou Zhiyan, Hu Yan, Liang Yuanyuan, Chen Tingting, Yang Yuhan, Jing Meng, Lei Dan, Pei Yang*, Xiaoan Li*, Selectivity mechanism of pyrrolopyridone analogues targeting bromodomain 2 of bromodomain-containing protein 4 from molecular dynamics simulations, ACS Omega, 2023, 8, 37, 33658–33674
(16) Guo Chuan#,*, Li Qinxuan#, Xiao Jiujia, Ma Feng, Xia Xun, Shi Mingsong*, Identification of defactinib derivatives targeting focal adhesion kinase using ensemble docking, molecular dynamics simulations, and binding free energy calculations, Journal of Biomolecular Structure and Dynamics, 2023, 41, 18, 8654-8670
(15) Shi Mingsong#, Liu Jiang #, Fu Suhong, Pei Heying, Peng Bin, Wen Yi, Wei Haoche, Zhou Xin, Chen Lijuan* and Xu Dingguo*, Structural insights into the interactions of belumosudil with rho-associated coiled-coil containing protein kinases 1 and 2 based on molecular docking, molecular dynamics simulations, and free energy calculations, Journal of Computational Biophysics and Chemistry, 2023, 22, 04, 401-422
(14) Zhou Yanting#, Li Xiandeng#, Luo Peifang, Chen Huiting, Zhou Yan, Zheng Xueting, Yin Yuan, Wei Haoche, Liu Hongji, Xia Wen*, Shi Mingsong*, Li Xiaoan, Identification of abemaciclib derivatives targeting cyclin-dependent kinase 4 and 6 using molecular dynamics, binding free energy calculation, synthesis, and pharmacological evaluation, Frontiers in pharmacology, 2023, 14, 1154654
(13) Shi Mingsong, Zhou Yan, Wei Haoche, Zhang Xinyu, Du Meng, Zhou Yanting, Yin Yuan, Li Xinghui, Tang Xinyi, Sun Liang, Xu Dingguo*, Li Xiaoan*, Interactions between curcumin and human salt-induced kinase 3 elucidated from computational tools and experimental methods, Frontiers in pharmacology, 2023, 14, 1116098
(12) Shi Mingsong, Chen Tao, Wei Siping, Zhao Chenyu, Zhang Xinyu, Li Xinghui, Tang Xinyi, Liu Yan, Yang Zhuang*, and Chen Lijuan*, Molecular docking, molecular dynamics simulations, and free energy calculation insights into the binding mechanism between VS-4718 and focal adhesion kinase, ACS Omega 2022, 7, 36, 32442-32456
(11) Shi Mingsong, Wang Lun, Liu Kongjun, Chen Yong, Hu Mengshi, Yang Linyu, He Jun, Chen Lijuan* and Xu Dingguo*, Molecular dynamics simulations of the conformational plasticity in the active pocket of salt-inducible kinase 2 (SIK2) multi-state binding with bosutinib, Computational and Structural Biotechnology Journal, 2022, 20, 2574-2586
(10) Shi Mingsong, He Jun, Weng Tiantian, Shi Na, Qi Wenyan, Guo Yong, Chen Tao, Chen Lijuan* and Xu Dingguo*, The binding mechanism of NHWD-870 to bromodomain-containing protein 4 based on molecular dynamics simulations and free energy calculation. Physical Chemistry Chemical Physics, 2022, 24, 8, 5125-5137
(9) Shi Mingsong, Zhou Xin, Cai Yao, Li Penghui, Yan Xinrong, Qin Dengxue, Du Meng, Li Shuo and Xu Dingguo*, Inhibition mechanism of hydroxyproline-like small inhibitors to disorder HIF-VHL interaction by molecular dynamic simulations and binding free energy calculations. Chinese Journal of Chemical Physics, 2021, 34, 6, 814-824
(8) Chen Tao？, Liu Yan？, Shi Mingsong？, Tang Minghai, Si Wenting, Yuan Xue, Wen Yi and Chen Lijuan*, Design, synthesis, and biological evaluation of novel covalent inhibitors targeting focal adhesion kinase. Bioorganic & Medicinal Chemistry Letters, 2021, 54, 15, 128433
(7) Liu Kongjun？, Li Dan？, Zheng Wei？, Shi Mingsong？, Chen Yong, Tang Minghai, Yang Tao, Zhao Min, Deng Dexin, Zhang Chufeng, Liu Jiang, Yuan Xue, Yang Zhuang* and Chen LiJuan*, Discovery, optimization, and evaluation of quinazolinone derivatives with novel linkers as orally efficacious phosphoinositide-3-kinase delta inhibitors for the treatment of inflammatory diseases. Journal of Medicinal Chemistry, 2021, 64, 13, 8951-8970
(6) Shi Mingsong？, Zhao Min ？, Wang Lun, Liu Kongjun, Li Penghui, Liu Jiang, Cai Xiaoying, Chen Lijuan* and Xu Dingguo*, Exploring the stability of inhibitor binding to SIK2 using molecular dynamics simulation and binding free energy calculation. Physical Chemistry Chemical Physics, 2021, 23, 23, 13216-13227
(5) Shi Mingsong, Wang Lun, Li Penghui, Liu Jiang, Chen Lijuan* and Xu Dingguo*, Dasatinib–SIK2 binding elucidated by homology modeling, molecular docking, and dynamics simulations. ACS Omega, 2021, 6, 16, 11025-11038
(4) Wang Lun？, Cai Xiaoying？, Shi Mingsong？, Xue Linlin, Kuang Shuang, Xu Ruiling, Qi Wenyan, Li Yan, Ma Xu, Zhang Ruijia, Hong Feng, Ye Haoyu* and Chen Lijuan*, Identification and optimization of piperine analogues as neuroprotective agents for the treatment of Parkinson’s disease via the activation of Nrf2/keap1 pathway, European Journal of Medicinal Chemistry, 2020, 199, 112385
(3) Shi Mingsong and Xu Dingguo*, Molecular dynamics investigations suggest a non-specific recognition strategy of 14-3-3δ protein by tweezer: implication for the inhibition mechanism. Frontiers in Chemistry, 2019, 7, 237
(2) Shi Mingsong, Xu Dingguo* and Zeng Jun*, GPU accelerated quantum virtual screening: application for the natural inhibitors of New Dehli Metalloprotein (NDM-1). Frontiers in Chemistry, 2018, 6, 564
(1) Shi Mingsong, Zhang Chunchun*, Xie Yani, Xu Dingguo*, Stereoselective inclusion mechanism of ketoprofen into β-cyclodextrin: insights from molecular dynamics simulations and free energy calculations. Theoretical Chemistry Accounts, 2014, 133, 10, 1556
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| 专业研究方向：
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| 专业名称 |
研究领域/方向 |
招生类别 |
| 071000生物学 |
01生物化学与分子生物学 |
硕士学术学位 |
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