导师个人信息 - 电子科大研招网

医学院

导师代码：	21164
导师姓名：	肖培宏
性别：	男
特称：
职称：	副研究员
学位：	理学博士学位
属性：	专职
电子邮件：	peihongxiao@uestc.edu.cn

学术经历：

2022.08 - 至今，电子科技大学附属四川省人民医院，副研究员； 2021.04 - 2022.05，香港科技大学，联合培养博士后； 2019.10 - 2022.05，深圳大学AIE研究中心，博士后； 2013.09 - 2018.06，四川大学，硕博连读； 2009.09 - 2013.06，四川大学，本科。

个人简介：

肖培宏，四川省人民医院副研究员，课题组长。四川省自然科学基金杰出青年基金获得者，天府峨眉计划青年人才项目入选者，四川省医学会精准医学专业青年委员会副主任委员，Exploration、Nano TransMed、IMed期刊青年编委，四川省卫生健康英才计划中青年骨干人才，四川省人民医院“双百工程”-优秀青年业务干部。主要从事疾病诊疗一体化探针开发及检验新技术与新方法研究，近5年共发表SCI论文20篇，所发表论文累计他引超过1100余次。主持国家自然科学面上项目、国家自然科学基金青年基金、四川省自然科学基金杰出青年基金等国家级和省部级项目4项，授权中国发明专利3项。

科研项目：

1. 国家自然科学基金面上项目：基于聚集诱导发光技术的新型时间分辨荧光侧流免疫层析检测平台的构建及其在结核病诊断方面的应用研究，项目批准号：82472381，主持，在研。 2. 国家自然科学基金青年科学基金：基于聚集诱导发光的深红/近红外荧光探针的合成及其在细菌成像和光动力杀菌中的应用研究，项目批准号：22007067，主持，已结题。 3. 四川省自然科学基金杰出青年基金：肿瘤微环境激活型近红外二区诊疗一体化探针的构建及应用研究，项目批准号：24NSFJQ0067, 主持，在研。 4. 中国博士后科学基金第67批面上资助：高尔基体靶向的聚集诱导发光诊疗一体化探针的设计、合成及应用研究，项目批准号：2020M672768，主持，已结题。

研究成果：

代表性论文： (1) Haixia Zhang, Yating Yang, Feiran Xie, Yu Lan, Lin Li, Zhenlei Song, Lu Gao, Yi Huang**, Peihong Xiao*, Endoplasmic reticulum-targeted fluorescent probe with aggregation-induced emission features for imaging peroxynitrite in drug-induced liver injury model, Biosens. Bioelectron., 2024, 262, 116573. (IF = 10.700) (2) Chenqi Guo, Mengying Wu, Zhaofei Guo, Rongping Zhang, Zijun Wang, Xiong Peng, Jianxia Dong, Xun Sun, Zhirong Zhang, Peihong Xiao*, Tao Gong*, Hypoxia-Responsive Golgi-Targeted Prodrug Assembled with Anthracycline for Improved Antitumor and Antimetastasis Efficacy, ACS Nano, 2023, 17, 24972-24987. (IF = 17.100) (3) Peihong Xiao#, Wei Xie#, Jianyu Zhang, Qian Wu, Zipeng Shen, Chenqi Guo, Yi Wu, Fubing Wang*, Ben Zhong Tang*, Dong Wang*. De Novo Design of Reversibly pH-Switchable NIR-II Aggregation-Induced Emission Luminogens for Efficient Phototheranostics of Patient-Derived Tumor Xenografts, J. Am. Chem. Soc., 2023, 145, 334-344. (IF = 16.806) (4) Yu Lan, Haixia Zhang, Ruichen Xie, Kecheng Li, Feiran Xie, Peihong Xiao*, Li Jiang*. An endoplasmic reticulum-targeted NIR fluorescent nanoprobe for early diagnosis of glaucoma in vivo, Sensors and Actuators B: Chemical, 2024, 406, 135441. (IF = 8.400) (5) Peihong Xiao; Zipeng Shen; Deliang Wang; Yinzhen Pan; Ying Li*; Junyi Gong; Lei Wang; Dong Wang*; Ben Zhong Tang*. Precise Molecular Engineering of Type I Photosensitizers with Near-Infrared Aggregation-Induced Emission for Image-Guided Photodynamic Killing of Multidrug Resistant Bacteria, Adv. Sci., 2022, 9, 2104079. (IF = 16.823) (6) Peihong Xiao#; Ke Ma#; Miaomiao Kang; Luyi Huang; Qian Wu; Nan Song;Jinyin Ge; Dan Li; Jianxia Dong; Lei Wang; Dong Wang*; Ben Zhong Tang*. An aggregation-induced emission platform for efficient Golgi apparatus and endoplasmic reticulum specific imaging, Chem. Sci., 2021, 12, 13949-13957. (IF = 9.825) (7) Peihong Xiao; Lu Gao; Zhenlei Song*. Recent Progress in the Transition-Metal-Catalyzed Activation of Si-Si Bonds to Form C-Si Bonds, Chem. Eur. J., 2019, 25, 2407-2422. (IF = 5.160) (8) Peihong Xiao; Yanjun Cao; Yingying Gui; Lu Gao; Zhenlei Song*. Me3Si-SiMe2[o-CON (iPr)2-C6H4]: An Unsymmetrical Disilane Reagent for Regio- and Stereoselective Bis-Silylation of Alkynes, Angew. Chem. Int. Ed., 2018, 57, 4769-4773. (inside cover，IF = 15.336) (9) Peihong Xiao, Zhixing Tang, Kai Wang, Hua Chen, Qianyou Guo, Yang Chu, Lu Gao* and Zhenlei Song*, Chemoselective Reduction of Sterically Demanding N, N-di (iso-propyl) Amides to Aldehydes. J. Org. Chem. 2018, 83, 1687？1700. (Featured article, Cover paper, IF = 4.849) (10) Zhijun Zhang, Wenhan Xu, Peihong Xiao, Miaomiao Kang, Dingyuan Yan, Haifei Wen, Nan Song, Dong Wang*, and Ben Zhong Tang*, Molecular Engineering of High-Performance Aggregation-Induced Emission Photosensitizers to Boost Cancer Theranostics Mediated by Acid-Triggered Nucleus-Targeted Nanovectors, ACS Nano 2021, 15, 10689-10699. (IF = 15.881) (11) Dan Li, Youmei Li, Qian Wu, Peihong Xiao, Lei Wang, Dong Wang*, Ben Zhong Tang*, Add the Finishing Touch: Molecular Engineering of Conjugated Small Molecule for High-Performance AIE Luminogen in Multimodal Phototheranostics, Small 2021, 17, 2102044. (IF = 13.281) (12) Ying Li, Fei Liu, Jiangjiang Zhang, Xiaoye Liu, Peihong Xiao, Haotian Bai, Shang Chen, Dong Wang, Simon H. P. Sung, Ryan T. K. Kwok, Jianzhong Shen, Kui Zhu*, Ben Zhong Tang*, Efficient Killing of Multidrug-Resistant Internalized Bacteria by AIEgens In Vivo, Adv. Sci. 2021, 8, 2001750. (IF = 16.823) (13) Xiujuan Shi，Simon H. P. Sung，Joe H. C. Chau，Ying Li，Zhiyang Liu，Ryan T. K. Kwok， Junkai Liu，Peihong Xiao，Jiangjiang Zhang，Bin Liu，Jacky W. Y. Lam，Ben Zhong Tang* Killing G(+) or G(-) Bacteria? The Important Role of Molecular Charge in AIE-Active Photosensitizers. Small Methods 2020, 4, 2000046. (IF = 12.130) (14) Zengjin Liu, Xinglong Lin, Na Yang, Zhishan Su, Changwei Hu, Peihong Xiao, Yanyang He, and Zhenlei Song*，Unique Steric Effect of Geminal Bis(silane) To Control the High Exo-selectivity in Intermolecular Diels–Alder Reaction. J. Am. Chem. Soc., 2016, 138, 1877–1883. (IF = 14.357) (15) Changzhen Sun，Yuebao Zhang, Peihong Xiao, Hongze Li, Xianwei Sun, and Zhenlei Song* Intramolecular [1,4]-S- to O-Silyl Migration: A Useful Strategy for Synthesizing Z-Silyl Enol Ethers with Diverse Thioether Linkages.Org. Lett., 2014, 16, 984–987. (IF = 6.492)

专业研究方向：