医学院
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| 导师代码： |
21050
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| 导师姓名： |
蒋鑫
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| 性 别： |
男 |
| 特 称： |
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| 职 称： |
教授
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| 学 位： |
博士学位
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| 属 性： |
专职 |
| 电子邮件： |
jiangx08@uestc.edu.cn
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| 学术经历：
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2008-2012 兰州大学 生命科学学院 学士
2012-2017 清华大学 生命科学学院 博士
2018-2019 普林斯顿大学 分子生物学系 博士后
2019-2023 新南威尔士大学（澳大利亚） 生物技术与生物分子系 高级研究员/助理教授
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| 个人简介：
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蒋鑫，教授，博士生导师，电子科技大学医学院/四川省医学科学院·四川省人民医院双聘教授，于 2023 年入选国家自然科学基金优秀青年科学基金（海外）项目，2024 年入选四川省 “天府峨眉计划” 青年人才。长期致力于基于生物化学和生物物理学的药物靶点机理研究，针对病原微生物和癌症相关膜蛋白靶标开展药物开发工作，具体研究方向包括：一是阐明重要癌症靶点的机制，深入研究人源葡萄糖转运蛋白（GLUTs）和单羧酸转运蛋白（MCTs）在癌细胞代谢重编程中的作用及抑制剂机理，为抗癌药物开发提供理论依据；二是开发靶向疟原虫营养吸收的新型抑制剂，探究疟原虫己糖转运蛋白（PfHT1）和乳酸转运蛋白（PfFNT）的转运与抑制机理，研发新型选择性抗疟药物。
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| 科研项目：
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1.国家自然科学基金优秀青年基金(海外)，主持
2.国家自然科学基金青年基金(C类)，主持
3.四川省自然科学基金青年科学基金A类，主持
4.四川省创新群体(免疫治疗研究团队)(团队骨干)
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| 研究成果：
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1.代表性成果列表
1)Cantao Quan; Xin Jiang; The molecular mechanism underlying the human glucose facilitators inhibition, Vitamins and Hormones, 2025,128:49-92
2)Lishu Chen; Qinghui Qi; Xiaoqing Jiang; Jin Wu; Yuanyuan Li; Zhaodan Liu; Yan Cai; Haohao Ran; Songyang Zhang; Cheng Zhang; Huiran Wu; Shuailiang Cao; Lanjuan Mi; Dake Xiao; Haohao Huang; Shuai Jiang; Jiaqi Wu; Bohan Li; Jiong Xie; Ji Qi; Fangye Li; Panpan Liang; Qiuying Han; Min Wu; Wenchao Zhou; Chenhui Wang; Weina Zhang; Xin Jiang; Kun Zhang; Huiyan Li; Xuemin Zhang; Ailing Li; Tao Zhou; Jianghong Man; Phosphocreatine promotes epigenetic reprogramming to facilitate glioblastoma growth through stabilizing BRD2, Cancer Discovery, 2024,18(4)
3)Xin Jiang; Nieng Yan; Dong Deng; Chuangye Yan; Structural aspects of the glucose and monocarboxylate transporters involved in the Warburg effect, IUBMB Life, 2022,74(9)
4)Nan Wang; Shuo Zhang; Yafei Yuan; Hanwen Xu; Elisabeth Defossa; Hans Matter; Melissa Besenius; Volker Derdau; Matthias Dreyer; Nis Halland; Kaihui Hu He; Stefan Petry; Michael Podeschwa; Norbert Tennagels; Xin Jiang; Nieng Yan; Molecular basis for inhibiting human glucose transporters by exofacial inhibitors, Nature Communications, 2022,13(1)
5)Xin Jiang; An overview of the Plasmodium falciparum hexose transporter and its therapeutic interventions, Protein & Cell, 2022,13(2)
6)Xi Peng; Nan Wang; Angqi Zhu; Hanwen Xu; Jialu Li; Yanxia Zhou; Chen Wang; Qingjie Xiao; Li Guo; Fei Liu; Zhi-Jun Jia; Huaichuan Duan; Jianping Hu; Weidan Yuan; Jia Geng; Chuangye Yan; Xin Jiang; Dong Deng; Structural characterization of the Plasmodium falciparum lactate transporter PfFNT alone and in complex with antimalarial compound MMV007839 reveals its inhibition mechanism, PLoS Biology, 2021,19(9)
7)Nan Wang; Xin Jiang; Shuo Zhang; Angqi Zhu; Yafei Yuan; Hanwen Xu; Jianlin Lei; Chuangye Yan; Orthosteric-allosteric dual inhibitors of PfHT1 as selective antimalarial agents, Proceedings of the National Academy of Sciences, 2021,118(1)
8)Jian Huang; Yafei Yuan; Na Zhao; Debing Pu; Qingxuan Tang; Shuo Zhang; Shuchen Luo; Xikang Yang; Nan Wang; Yu Xiao; Tuan Zhang; Zhuoyi Liu; Tomoyo Sakata-Kato; Xin Jiang; Nobutaka Kato; Nieng Yan; Hang Yin; Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates, Cell, 2020,183(26)
9)Xin Jiang; Yafei Yuan; Jian Huang; Shuo Zhang; Shuchen Luo; Nan Wang; Debing Pu; Na Zhao; Qingxuan Tang; Kunio Hirata; Xikang Yang; Yaqing Jiao; Tomoyo Sakata-Kato; Jia-Wei Wu; Chuangye Yan; Nobutaka Kato; Hang Yin; Nieng Yan; Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum, Cell, 2020,183(1)
10)Meng Gao; Jian Huang; Xin Jiang; Yafei Yuan; Huanhuan Pang; Shuchen Luo; Nan Wang; Chengbo Yao; Zuwan Lin; Debing Pu; Shuo Zhang; Pengcheng Sun; Zhuoyi Liu; Yu Xiao; Qian Wang; Zeping Hu; Hang Yin; Regulation of aerobic glycolysis to decelerate tumor proliferation by small molecule inhibitors targeting glucose transporters, Protein & Cell, 2020,11(5)
11)Xin Jiang; Jianping Wu; Meng Ke; Shuo Zhang; Yafei Yuan; Jason Ye Lin; Nieng Yan; Engineered XylE as a tool for mechanistic investigation and ligand discovery of the glucose transporters GLUTs, Cell Discovery, 2019,5(1)
12)Meng Ke; Yafei Yuan; Xin Jiang; Nieng Yan; Haipeng Gong; Molecular determinants for the thermodynamic and functional divergence of uniporter GLUT1 and proton symporter XylE, PLoS Computational Biology, 2017,13(6)
13)Xin Jiang; Irina Smirnova; Vladimir Kasho; Jianping Wu; Kunio Hirata; Meng Ke; Els Pardon; Jan Steyaert; Nieng Yan; H Ronald Kaback; Crystal structure of a LacY-anobody complex in a periplasmic-open conformation, Proceedings of the National Academy of Sciences, 2016,113(42)
14)Dong Deng; Pengcheng Sun; Chuangye Yan; Meng Ke; Xin Jiang; Lei Xiong; Wenlin Ren; Kunio Hirata; Masaki Yamamoto; Shilong Fan; Nieng Yan; Molecular basis of ligand recognition and transport by glucose transporters, Nature, 2015,523(7562)
15)Xu Zhang; Mengdie Xia; Yang Li; Huihui Liu; Xin Jiang; Wenlin Ren; Jianping Wu; Paul DeCaen; Feng Yu; Sheng Huang; Jianhua He; David E Clapham; Nieng Yan; Haipeng Gong; Analysis of the selectivity filter of the voltage-gated sodium channel NavRh, Cell Research, 2012,22(12)
2.专利
1)中国专利：用于筛选针对萄糖转运蛋白GLUT的结合剂的原核蛋白质及其制备方法和用途
2)中国专利：疟疾和恶性疟原虫已糖转运蛋白的抑制剂及其用途
3)澳大利专利：Inhibitors of malarial and Plasmodium falciparum hexose transporter and uses thereof
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| 专业研究方向：
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| 专业名称 |
研究领域/方向 |
招生类别 |
| 100200临床医学 |
06临床病理学 |
博士学术学位 |
| 071000生物学 |
01生物化学与分子生物学 |
硕士学术学位 |
| 105500药学 |
02药物研究与转化 |
硕士专业学位 |
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