医学院
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| 导师代码： |
21050
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| 导师姓名： |
蒋鑫
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| 性 别： |
男 |
| 特 称： |
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| 职 称： |
教授
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| 学 位： |
博士学位
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| 属 性： |
专职 |
| 电子邮件： |
jiangx08@uestc.edu.cn
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| 学术经历：
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2008年-2012年 兰州大学 生命科学学院 学士
2012年-2017年 清华大学 生命科学学院 博士
2018年-2019年 普林斯顿大学 分子生物学系 博士后
2019年-2024年 新南威尔士大学（澳大利亚） 生物技术与生物分子系 高级研究员
2024年-至今 电子科技大学医学院/四川省人民医院 教授/研究员
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| 个人简介：
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蒋鑫，电子科技大学医学院/四川省医学科学院·四川省人民医院双聘教授，博士生导师，国家级青年人才，四川省青年人才计划入选者、成都市青年人才计划入选者。团队致力于耐药性病原微生物和重要人类疾病的药物靶点和耐药性机制研究，利用基于人工智能的药物开发手段、SBDD、以及抗体筛选和蛋白质设计等手段，结合药物化学、药理学方法开发新型抗感染和抗癌疗法。具体方向包括：
1.病原微生物药物靶点机制研究和耐药性原理研究；
2.重要癌症药物靶点研究和靶向药物机制解析；
3.聚焦关键疾病的药物靶点，融合微型蛋白、抗体与多肽设计、人工智能及实验数据驱动的药物发现技术，开发新型抗感染和抗癌疗法。
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| 科研项目：
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1.国家自然科学基金优秀青年基金(海外)，主持
2.国家自然科学基金青年科学基金C类，主持
3.四川省自然科学基金青年科学基金A类，主持
4.四川省创新群体(免疫治疗研究团队)(骨干)
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| 研究成果：
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1.代表性成果列表
1) Ziyan Zhao#, Jialu Li#, Xinye Wang#, Xiaofeng Liu, Nan Wang, Hanwen Xu, Cantao Quan, Yu Gao, Jing Zhang, Xiang Wang, Li Guo, Nobutaka Kato, Dong Deng*, Xin Jiang*. Structural and mechanistic insights into the inhibition of Plasmodium falciparum MDR1. Nature Communications, 2026, 26: 2632
2) Cantao Quan, Xin Jiang. The molecular mechanism underlying the human glucose facilitators inhibition. Vitamins and Hormones, 2025, 128: 49-92
3) Lishu Chen#, Qinghui Qi#, Xiaoqing Jiang#, Jin Wu#, Yuanyuan Li, Zhaodan Liu, Yan Cai, Haowen Ran, Songyang Zhang, Cheng Wu, Huiran Cao, Shuailiang Mi, Lanjuan Xiao, Dake Huang, Haohao Jiang, Shuai Wu, Jiaqi Li, Bohan Xie, Jie Xiong, Qi Li, Fangye Liang, Panpan Han, Qiuying Wu, Min Zhou, Wenchao Wang, Chenhui Wang, Weina Zhang, Xin Jiang, Kun Zhang, Huiyan Li, Xuemin Zhang, Ailing Li, Tao Zhou*, Jianghong Man*. Phosphocreatine Promotes Epigenetic Reprogramming to Facilitate Glioblastoma Growth Through Stabilizing BRD2. Cancer Discovery, 2024, 14: 1547-1565
4) Xin Jiang, Nieng Yan, Dong Deng*, Chuangye Yan*. Structural aspects of the glucose and monocarboxylate transporters involved in the Warburg effect. IUBMB Life, 2022, 74: 1180-1199
5) Nan Wang, Shuo Zhang, Yafei Yuan, Hanwen Xu, Elisabeth Defossa, Hans Matter, Melissa Besenius, Volker Derdau, Matthias Dreyer, He Halland, Kaihui Hu, Stefan Petry, Michael Podeschwa, Norbert Tennagels, Xin Jiang*, Nieng Yan*. Molecular basis for inhibiting human glucose transporters by exofacial inhibitors. Nature Communications, 2022, 13: 2632
6) Xin Jiang. An overview of the Plasmodium falciparum hexose transporter and its therapeutic interventions. Proteins-Structure Function and Bioinformatics, 2022, 90: 1766-1778
7) Xi Peng#, Nan Wang#, Angqi Zhu#, Hanwen Xu#, Jialu Li#, Yanxia Zhou, Chen Wang, Qingjie Xiao, Li Guo, Fei Liu, Zhi-jun Jia, Huaichuan Duan, Jianping Hu, Weidan Yuan, Jia Geng, Chuangye Yan*, Xin Jiang*, Dong Deng*, Structural characterization of the Plasmodium falciparum lactate transporter PfFNT alone and in complex with antimalarial compound MMV007839 reveals its inhibition mechanism. PLOS Biology, 2022, 20: e3001632
8) Nan Wang#, Xin Jiang#*, Shuo Zhang, Angqi Zhu, Yafei Yuan, Hanwen Xu, Jianlin Lei, Chuangye Yan*, Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates. Cell, 2021, 184: 370
9) Jian Huang#, Yafei Yuan#, Na Zhao, Debing Pu, Qingxuan Tang, Shuo Zhang, Shuchen Luo, Xikang Yang, Nan Wang, Yu Xiao, Tuan Zhang, Zhuoyi Liu, Tomoyo SakataKato, Xin Jiang*, Nobutaka Kato*, Nieng Yan*, Hang Yin*. Orthosteric-allosteric dual inhibitors of PfHT1 as selective antimalarial agents. PNAS, 2021, 118: e2024566118
10) Xin Jiang#, Yafei Yuan#, Jian Huang#, Shuo Zhang#, Shuchen Luo, Nan Wang, Debing Pu, Na Zhao, Qingxuan Tang, Kunio Hirata, Xikang Yang, Yaqing Jiao, Tomoyo SakataKato, JiaWei Wu, Chuangye Yan, Nobutaka Kato, Hang Yin*, Nieng Yan*. Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum. Cell, 2020, 183: 1031-1043.e12
11) Meng Gao, Jian Huang, Xin Jiang, Yafei Yuan, Huanhuan Pang, Shuchen Luo, Nan Wang, Chengbo Yao, Zuwan Lin, Debing Pu, Shuo Zhang, Pengcheng Sun, Zhuoyi Liu, Yu Xiao, Qian Wang, Zeping Hu, Hang Yin. Regulation of aerobic glycolysis to decelerate tumor proliferation by small molecule inhibitors targeting glucose transporters. Protein & Cell, 2020, 13: 665-676
12) Xin Jiang, Jianping Wu, Meng Ke, Shuo Zhang, Yafei Yuan, Jason Ye Lin, Nieng Yan. Engineered XylE as a tool for mechanistic investigation and ligand discovery of the glucose transporters GLUTs. Cell Discovery, 2019, 7: 62
13) Meng Ke, Yafei Yuan, Xin Jiang, Nieng Yan, Haipeng Gong. Molecular determinants for the thermodynamic and functional divergence of uniporter GLUT1 and proton symporter XylE. PLOS Computational Biology, 2017, 14: e1006358
14) Xin Jiang, Irina Smirnova, Vladimir Kasho, Jianping Wu, Kunio Hirata, Meng Ke, Els Pardon, Jan Steyaert, Nieng Yan, H Ronald Kaback. Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation. PNAS, 2016, 117: 14986-14993
15) Dong Deng#, Pengcheng Sun#, Chuangye Yan, Meng Ke, Xin Jiang, Lei Xiong, Wenlin Ren, Kunio Hirata, Masaki Yamamoto, Shilong Fan, Nieng Yan. Molecular basis of ligand recognition and transport by glucose transporters. Nature, 2015, 526: 391-396
16) Xu Zhang#, Mengdie Xia#, Yang Li#, Huihui Liu#, Xin Jiang, Wenlin Ren, Jianping Wu, Paul DeCaen, Feng Yu, Sheng Huang, Jianhua He, David E Clapham, Nieng Yan, Haipeng Gong. Analysis of the selectivity filter of the voltage-gated sodium channel NavRh. Cell Research, 2013, 31: 409-422
2.专利
1)中国专利：用于筛选针对萄糖转运蛋白GLUT的结合剂的原核蛋白质及其制备方法和用途
2)中国专利：疟疾和恶性疟原虫已糖转运蛋白的抑制剂及其用途
3)澳大利专利：Inhibitors of malarial and Plasmodium falciparum hexose transporter and uses thereof
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| 专业研究方向：
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| 专业名称 |
研究领域/方向 |
招生类别 |
| 100200临床医学 |
06临床病理学 |
博士学术学位 |
| 071000生物学 |
01生物化学与分子生物学 |
硕士学术学位 |
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