生命科学与技术学院
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导师代码: |
21027
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导师姓名: |
卢凤梅
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性 别: |
女 |
特 称: |
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职 称: |
副研究员
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学 位: |
哲学博士学位
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属 性: |
兼职 |
电子邮件: |
fengmei_lu@126.com
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学术经历:
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[1] 2022-11至今,电子科技大学生命科学与技术学院,副研究员(双聘)
[2] 2021-07至今,成都市第四人民医院,电子科技大学成都脑科学研究院临床医院,副研究员
[3] 2018-03至2021-07,成都市第四人民医院,电子科技大学成都脑科学研究院临床医院,助理研究员
[4] 2018-07至2021-03,电子科技大学,生命科学与技术学院,博士后,合作导师:陈华富教授(****、杰青)
[5] 2014-08至2017-11,澳门大学,健康科学学院,博士,生物医药专业,导师:袁振教授
[6] 2011-09至2014-06,电子科技大学,生命科学与技术学院,硕士,生物医学工程专业,导师:陈华富教授(****、杰青)
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个人简介:
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卢凤梅,女,四川省海外高层次留学人才,电子科技大学博士后,澳门大学博士。电子科技大学成都脑科学研究院临床医院-成都市第四人民医院副研究员。主要从事多模态神经影像学技术及无创神经调控及其临床应用研究,主要研究方向为多模态脑影像分析、单双相抑郁症脑功能结构以及脑网络可塑性研究、无创神经调控技术及应用研究、人工智能模式识别算法等。近年来主持1项国家自然科学基金青年项目、1项四川省科技厅重点研发计划项目、1项四川省医学青年创新课题、1项中国博士后科学基金面上项目和2项神经信息教育部重点实验室开放课题基金,作为主要研究人员参与6项国家自然科学基金面上项目、1项成都市科技局重点研发项目、1项四川省卫生健康委员会医学科技项目和1项澳门科学技术发展基金项目。在神经科学Top期刊Cerebral Cortex、精神病学Top期刊Journal of Affective Disorders以及计算机科学Top期刊Neurocomputing等国际知名学术期刊上发表SCI论文70多篇,其中一作/共一,通讯/共同通讯作者论文32篇,Google学术引用1906余次,H指数25。获得2020年四川省医学科技奖(青年奖)三等奖(排名第2),2021年四川省医学青年科技奖三等奖(排名第2),2023年第二十届湖南省医学科技奖二等奖(排名第4),获得2023第八届全国大学生生命科学竞赛(创新创业类)二等奖(指导老师),获得四川省医学会2023年度青年优秀论文。取得3项脑影像处理相关软件著作权。发表EI收录的会议论文2篇,参与英文书籍章节编写两章。担任多个国际知名杂志编委以及审稿人,四川省科技厅项目评审专家,四川省医学会会员,中国神经科学学会会员,中国图象图形学学会会员,中国康复医学会精神卫生康复专业委员会青年工作组委员。
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科研项目:
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[1] 四川省医学青年创新课题,Q23078,iTBS干预青少年抑郁症认知功能和自杀意念的神经机制及疗效机制研究,2024.01-2026.12,1万,主持。
[2] 四川省科技计划项目(重点研发项目),四川省科技厅重点研发计划项目,2022YFS0180,Theta爆发式磁刺激干预伴自杀未遂青少年抑郁症脑可塑性变化的多模态脑影像人工智能关键方法研究,2022.01-2023.12,20万,在研,主持。
[3] 国家自然科学基金青年项目,62006038,伴自杀未遂青少年抑郁症rTMS调控神经机制的脑网络关键方法研究,2021.01-2023.12,24万,已结题,主持。
[4] 成都市科技局重点研发项目,2022-YF09-00023-SN,基于数字疗法的青少年抑郁症远程心理干预系统开发与推广应用,2023.01-2025.12,100万,在研,主研(排名第三)
[5] 神经信息教育部重点实验室开放课题基金,ZYG2020K005-3,基于模式识别的抑郁症rTMS治疗的脑影像神经机制研究,2020.08-2021.12,2万,已结题,主持。
[6] 中国博士后科学基金面上项目,2019M653383,个体化靶点rTMS干预青少年抑郁症的影像学神经机制研究,2019.03-2020.12,8万,已结题,主持。
[7] 神经信息教育部重点实验室开放课题基金,ZYGX2019K005,青少年抑郁症rTMS治疗的多模态磁共振影像学机制研究,2019.10-2020.12,2万,已结题,主持。
[8] 国家自然科学基金面上项目,62173069,解释偏向介导抑郁症自杀意念的神经机制研究,2022.01-2025.12,57万,在研,主研(排名第二)。
[9] 四川省卫生健康委员会医学科技项目,21PJ148,基于近红外光谱成像技术 (FNIRS) 的重复经颅磁刺激术 (rTMS) 治疗首发抑郁症潜在刺激靶点研究,2021.12-2023.10,15万,主研(排名第二)。
[10] 国家自然科学基金面上项目,62276049,基于图卷积的多模态磁共振图像精神分裂症诊断方法研究,2023.01-2026.12,54万元,在研,主研(排名第四)。
[11] 国家自然科学基金面上项目,62176044,基于抑郁环路精细脑图谱研究抑郁症电休克治疗神经机制和个体化预测,2022.01-2025.12,59万,在研,主研(排名第三)。
[12] 国家自然科学基金面上项目,82172059,单双相抑郁障碍多模态脑网络机制与智能化诊疗方法研究,2022.01-2025.12,55万,在研,主研(排名第四)。
[13] 国家自然科学基金面上项目,62073058,精神分裂症患者药物治疗前后脑可塑性变化的个体化影像学方法研究,2021.01-2024.12,58万,在研,主研(排名第二)。
[14] 国家自然科学基金面上项目,61876114,自然场景脑认知图像编解码特征提取与识别技术研究,2019.01-2022.12,62万,已结题,主研(排名第三)。
[15] 澳门科学技术发展基金,FDCT 025/2015/A1,使用融合的脑电和近红外光谱成像研究运动疗法治疗脑瘫的效果,2015.10-2019.3,204.5万澳门币,已结题,主研。
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研究成果:
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一、获得奖项:1. 获得2020年度四川省医学科技奖(青年奖),三等奖,排名第2。2. 获得2021年度四川省医学青年科技奖,三等奖,排名第2。3. 获得2023年第八届全国大学生生命科学竞赛(创新创业类)二等奖,指导老师。4. 《Insular-associated causal network of structural covariance evaluating progressive gray matter changes in major depressive disorder》获得四川省医学会2023年度青年优秀论文。5. 获2023年度第二十届湖南医学科技奖,二等奖,排名第4。6. 获2021年度科技突出贡献奖三等奖(成都市第四人民医院,2022.1)。7. 在2020年疫情防控工作中做出积极贡献,获得嘉奖(成都市第四人民医院,2022.01)。二、软件著作权:[1]成都市第四人民医院,卢凤梅,陈恒,贺碧芳。磁共振脑影像原点定位软件。登记号:2019SR1177413。[2]成都市第四人民医院,卢凤梅,贺碧芳,陈恒。基于深度卷积神经网络预测植物病毒衍生的小干扰RNA软件。登记号:2019SR1211158。[3]成都市第四人民医院,卢凤梅,陈恒,郑俊杰。基于NL-means算法的图像去噪处理软件。登记号:2019SR0718859。[4]陈华富,陈恒,何长春,郭肖楠,卢凤梅,段旭君。双聚类大脑皮层下脑区亚区定位软件。登记号:2019SR0772808。三、发表文章(一作/共一/通讯/共通讯):[1] Fengmei Lu, Qian Cui*, Yang Zou, Yuanhong Guo, Wei Luo, Yue Yu, Jingjing Gao, Xiao Cai, Linna Fu, Shuai Yuan, Juan Huang, Yajun Zhang, Jing Xie, Wei Sheng, Qin Tang, Qing Gao*, Zongling He*, Huafu Chen*.(2023). Effects of rTMS Intervention on Functional Neuroimaging Activities in Adolescents with Major Depressive Disorder Measured Using Resting-State fMRI. Bioengineering (Basel). 10 (12), 1374. [2]Weiqi Zhou, Jueyan Wu, Yan Li, Jie Li, Mengli Sun, Rong Li, Chengbo Yang, Mu Zhang, Lisha Gong, Jiali Yu, Jinsong Leng, Qin Chen, Fengmei Lu*, Huafu Chen*, Qing Gao*. (2023). The Antagonistic Alterations of Cerebellar Functional Segregation and Integration in Athletes with Fast Demands of Visual-Motor Coordination. Cognitive Computation. 1-12. [3]Xianliang Chen, Hui Chen, Jiali Liu, Huajia Tang, Jiawei Zhou, Peiqu Liu, Yusheng Tian, Xiaoping Wang, Fengmei Lu*, Jiansong Zhou*. (2023). Functional connectivity alterations in reward-related circuits associated with non-suicidal self-injury behaviors in drug-na?ve adolescents with depression. Journal of Psychiatric Research. 163: 270-277. [4] Fengmei Lu#, Yuanhong Guo#, Wei Luo#, Yue Yu#, Yi Zhao, Shuai Ni, Jiajia Chen, Xiao Cai, Chuntao Shen, Xiaoping Wang, Jiangjun He*, Guocheng Yang*, Qing Gao*, Zongling He*, Jiansong Zhou*. (2023). Disrupted functional networks within white-matter served as neural features in adolescent patients with conduct disorder. Behavioural Brain Research. 447, 114422. [5]Yi Zhao#, Zongling He#, Wei Luo, Yue Yu, Jiajia Chen, Xiao Cai, Jingjing Gao, Lingjiang Li, Qing Gao, Huafu Chen, Fengmei Lu*. (2023). Effect of intermittent theta burst stimulation on suicidal ideation and depressive symptoms in adolescent depression with suicide attempt: A randomized sham-controlled study. Journal of Affective Disorders. 325: 618-626. [6]Fengmei Lu, Yanchi Chen, Qian Cui*, Yuanhong Guo, Yajing Pang, Wei Luo, Yue Yu, Jiajia Chen, Jingjing Gao, Wei Sheng, Qin Tang, Yuhong Zeng, Kexing Jiang, Qing Gao*, Zongling He*, Huafu Chen*. (2023). Shared and distinct patterns of dynamic functional connectivity variability of thalamo-cortical circuit in bipolar depression and major depressive disorder. Cerebral Cortex. 33(11): 6681-6692. [7]Yan Li#, Yang Zhang#, Weiqi Zhou, Rong Li, Jiali Yu, Lisha Gong, Jinsong Leng, Fengmei Lu*, Jingming Hou*, Huafu Chen*, Qing Gao*. (2023). Depression mediated the relationships between precentral-subcortical causal links and motor recovery in spinal cord injury patients. Cerebral Cortex. 33(11): 7250-7257. [8]Zhengning Wang, Yuhang Xu, Dawei Peng, Jingjing Gao*, Fengmei Lu*. (2023). Brain functional activity-based classification of autism spectrum disorder using an attention-based graph neural network combined with gene expression. Cerebral Cortex. 33(10): 6407-6419. [9]Fengmei Lu, Qian Cui*, Yuyan Chen, Zongling He, Wei Sheng, Qin Tang, Yang Yang, Wei Luo, Yue Yu, Jiajia Chen, Di Li, Jiaxin Deng, Yuhong Zeng, Huafu Chen*. (2023). Insular-associated causal network of structural covariance evaluating progressive gray matter changes in major depressive disorder. Cerebral Cortex. 33(3): 831-843. [10]Huachang Zhao, Sijia Lu, Xiaoyan Li, Panyun Huang, Hongming Wang*, Fengmei Lu*. (2022). Multidisciplinary Collaboration in Diagnosis and Treatment of Neuroleptic Malignant Syndrome Complicated with Pneumonia: Report of Three Cases. Diagnostic Pathology. [11]Zongling He, Fengmei Lu*. (2022). Commentary: Aberrant Dynamic Functional Connectivity of Posterior Cingulate Cortex Subregions in Major Depressive Disorder With Suicidal Ideation. Frontiers in Neuroscience. 16: 1012050. [12]Song Wang*, Jiang Jiang, Xin Tang, Fengmei Lu*. (2022). Editorial: New Advances in Grit Research: A Multidisciplinary Perspective. Frontiers in Psychology. 13: 967591. [13]Fengmei Lu, Qian Cui*, Zongling He, Wei Sheng, Yajing Pang, Yuyan Chen, Qin Tang, Yang Yang, Wei Luo, Yue Yu, Di Li, Jiaxin Deng, Shan Hu, Huafu Chen*. (2021). Prefrontal-limbic-striatum dysconnectivity associated with negative emotional endophenotypes in bipolar disorder during depressive episodes. Journal of Affective Disorders. 295:422-430. [14]Fengmei Lu, Qian Cui*, Zongling He, Qin Tang, Yuyan Chen, Wei Sheng, Yang Yang, Wei Luo, Yue Yu, Jiajia Chen, Di Li, Jiaxin Deng, Shan Hu, Huafu Chen*. (2021). Superficial white-matter functional networks changes in bipolar disorder patients during depressive episodes. Journal of Affective Disorders. 289:151-159. [15]Heng Chen#, Fengmei Lu#, Xiaonan Guo, Yajing Pang, Changchun He, Shaoqiang Han, Xujun Duan*, Huafu Chen*. (2021). Dimensional analysis of atypical functional connectivity of major depression disorder and bipolar disorder. Cerebral Cortex. 32(6):1307-1317. [16]Fengmei Lu#, Yi Zhao#, Zongling He#, Xujing Ma#, Xudong Yao, Peiqu Liu, Xiaoping Wang, Guocheng Yang*, Jiansong Zhou*. (2021). Altered dynamic regional homogeneity in patients with conduct disorder. Neuropsychologia. 157: 107865. [17] Fengmei Lu, Yi Zhao, Zongling He, Wei Luo, Yue Yu, Jiajia Chen, Jing Du, Jiansong Zhou*. (2021). Altered White-Matter Functional Networks in Patients With Conduct Disorder. International Journal of Psychophysiology 168, S181-S182. [18]Xueyu Lv#, Fengmei Lu#, Jinhua Zhang, Heng Chen, Liang Zhang, Xiaoling Wang, Yangyang Fan, Jiliang Fang, Lan Hong, Jian Wang, Chunhong Liu, Zhen Yuan, Zongling He*, Weidong Wang*. (2021). Effects of TIP treatment on brain network topology of frontolimbic circuit in first-episode, treatment-na?ve major depressive disorder. Journal of Affective Disorders. 279: 122-130. [19]Fengmei Lu, Peiqu Liu, Heng Chen, Mengyun Wang, Shiyang Xu, Zhen Yuan, Xiaoping Wang, Song Wang*, Jiansong Zhou*. (2020). More than just statics: abnormal dynamic amplitude of low-frequency fluctuation in adolescent patients with pure conduct disorder. Journal of Psychiatric Research. 131: 60-68. [20]Xujing Ma#, Fengmei Lu#, Caihong Hu, Jiao Wang, Sheng Zhang, Shuqin Zhang, Guiran Yang*, Jiuquan Zhang*. (2020). Dynamic Alterations of Spontaneous Neural Activity in Patients with Amyotrophic Lateral Sclerosis. Brain Imaging and Behavior. 15(4): 2101-2108. [21]Heng Chen#, Fengmei Lu#, Bifang He*. (2020). Topographic Property of Backpropagation Artificial Neural Network: From human functional connectivity network to artificial neural network. Neurocomputing. 418: 200-210. [22]Zongling He#, Jiajia Chen#, Keliang Pan#, Yuchuan Yue, Teris Cheung, Yin Yuan, Na Du, Yan Zhao, Yusu Feng, Die Zhou, You Zhou, Fengmei Lu*, Yong Chen*, Manxi He*, Yu-Tao Xiang. (2020). The development of the ‘COVID-19 Psychological Resilience Model’ and its efficacy during the COVID-19 pandemic in China. International Journal of Biological Sciences. 16(15): 2828. [23]Fengmei Lu, Mengyun Wang, Shiyang Xu, Heng Chen, Zhen Yuan, Lizhu Luo, Xiuli Wang, Jiang Zhang, Jing Dai, Xiaoping Wang, Huafu Chen, Jiansong Zhou*. (2020). Decreased interhemispheric resting-state functional connectivity in male adolescents with conduct disorder. Brain Imaging and Behavior 15. 1201–1210. [24] Fengmei Lu, Qian Cui*, Xinju Huang, Liyuan Li, Xujun Duan, Heng Chen, Yajing Pang, Zongling He, Wei Sheng, Shaoqiang Han, Yuyan Chen, Yang Yang, Wei Luo, Yue Yu, Xiaohan Jia, Qin Tang, Di Li, Ailing Xie, Huafu Chen*. (2020). Anomalous intrinsic connectivity within and between visual and auditory networks in major depressive disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 100: p. 109889. [25]Zongling He#, Fengmei Lu#, Wei Sheng, Shaoqiang Han, Yajing Pang, Yuyan Chen, Qin Tang, Yang Yang, Wei Luo, Yue Yu, Xiaohan Jia, Di Li, Ailing Xie, Qian Cui*, Huafu Chen*. (2020). Abnormal functional connectivity as neural biological substrate of trait and state characteristics in major depressive disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 102: p. 109949. [26]ShiYang Xu#, Fengmei Lu#, Mengyun Wang, Zhishan Hu, Juan Zhang, Zhiyi Chen, Paulo A. S Armada-da-Silva, Zhen Yuan*. Altered functional connectivity in the motor and prefrontal cortex for children with Down’s syndrome: an fNIRS study. (2020). Frontiers in Human Neuroscience. [27]Guocheng Yang, Dongfen Li, Yunbo Rao*, Fengmei Lu*. (2020). The relationship between cortical thickness and language comprehension varies with sex in healthy young adults: a large sample analysis. NeuroReport. 31(2): 184-188. [28]Huiduo Wu#, Fengmei Lu#, Bin Yu, Qiaoyun Liu*. (2019). Phonological acquisition and development in Putonghua-speaking children with Autism Spectrum Disorders. Clinical Linguistics & Phonetics, 1-17. [29]Zongling He#, Fengmei Lu#, Wei Sheng, Shaoqiang Han, Zhiliang Long, Yuyan Chen, Wei Luo, Yue Yu, Xiaoyu Nan, Aili Ouyang, Qian Cui, Huafu Chen*. (2019). Functional dysconnectivity within the emotion-regulating system is associated with affective symptoms in major depressive disorder: A resting-state fMRI study. Australian and New Zealand Journal of Psychiatry, 53(6): p. 528-539. [30]Fengmei Lu#, Jing Dai#, Tania A. Couto, Chunhong Liu, Heng Chen, Shunli Lu, Lirong Tang, Changle Tie, Huafu Chen, Manxi He, Yu-Tao Xiang, Zhen Yuan*. Diffusion tensor imaging tractography reveals disrupted white matter structural connectivity network in healthy adults with insomnia symptoms. (2017). Frontiers in Human Neuroscience. 11(583). [31] Fengmei Lu, Chunhong Liu, Shunli Lu, Lirong Tang, Changle Tie, Juan Zhang, Zhen Yuan*. (2017). Disrupted Topology of Frontostriatal Circuits Is Linked to the Severity of Insomnia. Frontiers in Neuroscience, 11(214). [32] Fengmei Lu, Jiansong Zhou, Xiaoping Wang, Yutao Xiang, Zhen Yuan*. (2017). Short- and long-range functional connectivity density alterations in adolescents with pure conduct disorder at resting-state. Neuroscience, 351, 96-107. [33] Fengmei Lu, Yifeng Wang, Juan Zhang, Huafu Chen, Zhen Yuan*. Optical mapping of the dominant frequency of brain signal oscillations in motor systems. (2017). Scientific Reports. 7(1), 14703. [34]Fengmei Lu, Jiansong Zhou*, Jiang Zhang, Yutao Xiang, Jian Zhang, Qi Liu, Xiao-Ping Wang, Zhen Yuan*. (2015). Functional connectivity estimated from resting-state fMRI reveals selective alterations in male adolescents with pure conduct disorder. PloS One. 10(12):e0145668. [35]Fengmei Lu, Yajun Huo, Meiling Li, Heng Chen, Feng Liu, Yifeng Wang, Zhiliang Long, Xujun Duan, Jiang Zhang, Ling Zeng, Huafu Chen*. (2014). Relationship between personality and gray matter volume in healthy young adults: a voxel-based morphometric study. PloS One, 9(2), e88763.
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专业研究方向:
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专业名称 |
研究领域/方向 |
招生类别 |
083100生物医学工程 |
02医学成像与图像处理技术,03生物医学信号与信息处理 |
硕士学术学位 |
085409生物医学工程 |
01不区分研究方向,02不区分研究方向(非全) |
硕士专业学位 |
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