医学院
|
|
|
|
导师代码: |
20796
|
导师姓名: |
张新军
|
性 别: |
男 |
特 称: |
国家级青年人才
|
职 称: |
教授
|
学 位: |
理学博士学位
|
属 性: |
专职 |
电子邮件: |
xzhang@uestc.edu.cn
|
|
|
学术经历:
|
|
1996-2000 北京大学医学部 药学 学士;2000-2006 清华大学医学院 生物学博士;2006-2016 美国哈佛医学院波士顿儿童医院 博士后/Instructor;2016-2023 华中科技大学生命科学与技术学院教授;2023年加入电子科技大学医学院和四川省医学科学院·四川省人民医院。
|
|
个人简介:
|
|
张新军,教授,博士生导师,国家级青年人才,四川省领军人才。电子科技大学医学院和四川省医学科学院·四川省人民医院遗传中心教授。主要从事Wnt通路和细胞内囊泡运输调控机制以及相关的疾病和转化研究。相关工作以第一作者或通讯作者发表于Cell, Dev Cell, Mol Cell, Autophagy, EMBO Reports, JBC等学术期刊。2015年入选国家海外高层次人才引进计划青年项目(优先资助)。
|
|
科研项目:
|
|
1)电子科技大学高层次人才引进项目和四川省人民医院引进人才启动项目;
2)自然科学基金面上项目,2019-2022,57万,主持;2025-2028, 50万, 主持;
3)四川省自然科学基金面上项目,2024-2025, 20万,主持;
4)国家海外高层次人才引进计划青年项目,300万,主持。
|
|
研究成果:
|
|
代表性论文
1. Li M, Zheng J, Luo D, Xu K, Sheng R, MacDonald BT, He X, Zhang X. Frizzled receptors facilitate Tiki inhibition of Wnt signaling at the cell surface. EMBO Rep. 2023 Jun 5;24(6):e55873. doi: 10.15252/embr.202255873.
2. Pei Y, Lv S, Shi Y, Jia J, Ma M, Han H, Tan J, Zhang X. Rab21 controls autophagy and cellular energy homeostasis by regulating retromer-mediated recycling of GLUT1. Autophagy. 2023 Apr;19(4):1070-1086. doi: 10.1080/15548627.2022.2114271.
3. Zheng S, Lin J, Pang Z, Zhang H, Wang Y, Ma L, Zhang H, Zhang X, Chen M, Zhang X, Zhao C, Qi J, Cao L, Wang M, He X, Sheng R. Aberrant Cholesterol Metabolism and Wnt/β-Catenin Signaling Coalesce via Frizzled5 in Supporting Cancer Growth. Adv Sci (Weinh). 2022 Oct;9(28):e2200750. doi: 10.1002/advs.202200750.
4. Choi RB, Bullock WA, Hoggatt AM, Horan DJ, Pemberton EZ, Hong JM, Zhang X, He X, Robling AG. Notum Deletion From Late-Stage Skeletal Cells Increases Cortical Bone Formation and Potentiates Skeletal Effects of Sclerostin Inhibition. J Bone Miner Res. 2021 Dec;36(12):2413-2425. doi: 10.1002/jbmr.4411.
5. Li M, Zheng J, Luo D, Xu K, Zhang X. Tiki Proteins are Substrates of Membrane-type Matrix Metalloproteinases. FEBS Lett. 2022 Jul; 596(14):1851-1859. doi: 10.1002/1873-3468.14423.
6. Li M, Zheng J, He X, Zhang X. Tiki proteins are glycosylphosphatidylinositol-anchored proteases. FEBS Lett. 2022 Apr; 596(8):1037-1046. doi: 10.1002/1873-3468.14320.
7. Zhang X, He X. Methods for Studying Wnt Protein Modifications/Inactivations by Extracellular Enzymes, Tiki and Notum. Methods Mol Biol. 2016; 1481: 29-38.
8. Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R, Zhang X, Stallcup WB, Miao J, He X, Hurdle JG, Breault DT, Brass AL, Dong M. Frizzled proteins are colonic epithelial receptors for C. difficile toxin B. Nature. 2016 Oct 20;538(7625):350-355. doi: 10.1038/nature19799.
9. Zhang X, Macdonald BT, Gao H, Shamashkin M, Coyle AJ, Martinez RV, He X. Characterization of Tiki, a New Family of Wnt-specific Metalloproteases. J Biol Chem. 2016 Jan 29; 291(5): 2435-43.
10. Zhang X, Cheong SM, Amado NG, Reis AH, MacDonald BT, Zebisch M, Jones EY, Abreu JG, Xi He. Notum is required for neural and head induction via Wnt deacylation, oxidation and inactivation. Dev Cell. 2015 Mar 23; 32(6): 719-30.
11. Zhang X, He X. PAF makes it EZ(H2) for β-catenin transactivation. Mol Cell. 2013 Oct 24; 52(2):157-8.
12. Kim SE, Huang H, Zhao M, Zhang X, Zhang A, Semonov MV, MacDonald BT, Zhang X, Garcia Abreu J, Peng L, He X. Wnt stabilization of β-catenin reveals principles for morphogen receptor-scaffold assemblies. Science. 2013 May 17;340(6134):867-70. doi: 10.1126/science.1232389.
13. Zhang X, Abreu JG, Yokota C, Macdonald BT, Singh S, Coburn KL, Cheong SM, Zhang MM, Ye QZ, Hang HC, Steen H, He X. Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation. Cell. 2012 Jun 22; 149(7): 1565-77.
14. Semenov MV, Zhang X, He X. DKK1 antagonizes Wnt signaling without promotion of LRP6 internalization and degradation. J Biol Chem. 2008 Aug 1; 283(31):21427-32.
15. Zeng X, Huang H, Tamai K, Zhang X, Harada Y, Yokota C, Almeida K, Wang J, Doble B, Woodgett J, Wynshaw-Boris A, Hsieh JC, He X. Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions. Development. 2008 Jan; 135(2):367-75.
16. Zhang X, He X, Fu XY, Chang Z. Varp is a Rab21 guanine nucleotide exchange factor and regulates endosome dynamics. J Cell Sci. 2006 Mar 15; 119(Pt 6):1053-62.
17. Tamai K, Zeng X, Liu C, Zhang X, Harada Y, Chang Z, He X. A mechanism for Wnt coreceptor activation. Mol Cell. 2004 Jan 16; 13(1):149-56.
|
|
专业研究方向:
|
专业名称 |
研究领域/方向 |
招生类别 |
100200临床医学 |
11肿瘤学 |
博士学术学位 |
071000生物学 |
01生物化学与分子生物学,04细胞生物学 |
硕士学术学位 |
100200临床医学 |
06临床检验诊断学 |
硕士学术学位 |
|
|
|
|
|