医学院
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| 导师代码： |
20532
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| 导师姓名： |
钱浩
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| 性 别： |
男 |
| 特 称： |
国家级青年人才
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| 职 称： |
教授
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| 学 位： |
理学博士学位
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| 属 性： |
专职 |
| 电子邮件： |
qianhao@uestc.edu.cn
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| 学术经历：
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2007年毕业于华中科技大学同济医学院公共卫生学院，获得预防医学学士学位。随后进入中国科学院生物物理研究所继续深造，主要研究方向是中枢神经系统信号传导的生理基础和病理改变。2013年获得神经生物学博士学位后，在美国加州大学圣迭戈分校继续从事神经退行性疾病的相关研究。2021年加入电子科技大学医学院。
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| 个人简介：
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钱浩教授长期从事神经系统相关研究，致力于将基础科研与临床应用结合起来，利用解决神经科学基本问题过程中所获得的重要成果指导针对神经系统疾病治疗新策略的开发。在加州大学圣迭戈分校工作期间，与其他同事共同阐明了神经元转分化的关键性调控通路，开发了将人源成纤维细胞高效重编程为神经元的方法。在此基础上，进一步建立起诱导星形胶质细胞转分化为神经元的技术路线。这一方法能在哺乳动物大脑中直接产生新生神经元，并重建被破坏的神经通路，改善帕金森症动物的症状。为研发治疗一系列神经退行性疾病的临床策略提供了新的思路。
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| 科研项目：
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1，星形胶质细胞向神经元转分化的机制
2，RNA转录后加工与视网膜疾病的发生
3，神经系统疾病新治疗方法的开发
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| 研究成果：
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1. Hao Qian, Xinjiang Kang, Jing Hu, Dongyang Zhang, Zhengyu Liang, Fan Meng, Xuan Zhang, Yuanchao Xue, Roy Maimon, Zhuan Zhou, Neal K. Devaraj, Steven F. Dowdy, William C. Mobley, Don W. Cleveland, Xiang-Dong Fu Reversing Parkinson Disease Model with in situ Converted Nigral Neurons Nature, 2020; 582 (7813): 550-556
2. Yue Peng, Jiali He, Hongling Xiang, Lei Xie, Jin She, Donghui Cheng, Bei Liu, Jing Hu, Hao Qian Potential Impact of Hypoxic Astrocytes on the Aggravation of Depressive Symptoms in Parkinson's Disease Journal of Molecular Neuroscience, 2024 accepted
3. Shicheng Jiang, Bei Liu, Kaiwen Lin, Lianjun Li, Rongrong Li, Shuo Tan, Xinyu Zhang, Lei Jiang, Hong Ni, Yuanyuan Wang, Haihu Ding, Jing Hu, Hao Qian, Rongjing Ge Impacted spike frequency adaptation associated with reduction of KCNQ2/3 exacerbates seizure activity in temporal lobe epilepsy Hippocampus, 2024; 34(2):58-72
4. Liu Bei, He JiaLi, Wang ZiYan, Huang Xiang, Hu Jing, Qian Hao Clustering analysis of microglial subpopulations in midbrain of Parkinson’s disease patients Sci Sin Vitae, 2023, 53: 1298–1309
5. Bei Liu, Jiali He, Ling Zhong, Lulin Huang, Bo Gong, Jing Hu, Hao Qian, Zhenglin Yang Single-cell transcriptome reveals diversity of Müller cells with different metabolic-mitochondrial signatures in normal and degenerated macula Frontiers in Neuroscience, 2022; 10.3389/fnins.2022.1079498
6. Hao Qian and Xiang-Dong Fu Genetic Brain Repair by Cell Replacement via In Situ Neuronal Reprogramming Annual Review of Genetics, 2021; 55:45–69
7. Yuanchao Xue*, Hao Qian*, Jing Hu, Bing Zhou, Yu Zhou, Xihao Hu, Aziz Karakhanyan, Zhiping Pang, Xiang-Dong Fu Sequential regulatory loops as key gatekeepers for neuronal reprogramming in human cells Nature neuroscience, 2016; 19(6): 807–815. (* equal contribution)
8. Bo Wen*, Hao Qian*, Jing Feng, Rong‐Jing Ge, Xin Xu, Zhi‐Qiang Cui, Ru‐Yuan Zhu, Long‐Sheng Pan, Zhi‐Pei Lin, Jin‐Hui Wang A portion of inhibitory neurons in human temporal lobe epilepsy are functionally upregulated: an endogenous mechanism for seizure termination CNS neuroscience & therapeutics, 2014; 21 (2): 204-214. (* equal contribution)
9. Jiandong Yu*, Hao Qian*, Na Chen, JH Wang Quantal glutamate release is essential for reliable neuronal encodings in cerebral networks PLoS One, 2011; 6(9): e25219 (* equal contribution)
10. Jing Hu, Hao Qian, Yuanchao Xue, Xiang-Dong Fu PTB/nPTB: master regulators of neuronal fate in mammals Biophysics reports, 2018; 4 (4): 204–214
11. Liang Chen, Jia-Yu Chen, Yi-Jou Huang, Ying Gu, Jinsong Qiu, Hao Qian, Changwei Shao, Xuan Zhang, Jing Hu, Hairi Li, Shunmin He, Yu Zhou, Omar Abdel-Wahab, Dong-Er Zhang, Xiang-Dong Fu The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations Molecular cell, 2018; 69(3): 412–425.
12. Liang Chen, Jia-Yu Chen, Xuan Zhang, Ying Gu, Rui Xiao, Changwei Shao, Peng Tang, Hao Qian, Daji Luo, Hairi Li, Yu Zhou, Dong-Er Zhang, Xiang-Dong Fu R-ChIP Using Inactive RNase H Reveals Dynamic Coupling of R-loops with Transcriptional Pausing at Gene Promoters Molecular cell, 2017; 68(4): 745–757.
13. Zhen-Ning Zhang, Beatriz C Freitas, Hao Qian, Jacques Lux, Allan Acab, Cleber A Trujillo, Roberto H Herai, Viet Anh Nguyen Huu, Jessica H Wen, Shivanjali Joshi-Barr, Jerome V Karpiak, Adam J Engler, Xiang-Dong Fu, Alysson R Muotri, Adah Almutairi Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction Proceedings of the National Academy of Sciences, 2016; 113(12): 3185–3190
14. Rongjing Ge, Hao Qian, Na Chen, Jin-Hui Wang Input-dependent subcellular localization of spike initiation between soma and axon at cortical pyramidal neurons Molecular Brain, 2014; 7(26)
15. Jiandong Yu, Hao Qian, JH Wang Upregulation of transmitter release probability improves a conversion of synaptic analogue signals into neuronal digital spikes Molecular Brain, 2012; 5(26)
16. Haiyun Tang, Hongyu Long, Chang Zeng, Yi Li, Fangfang Bi, Jinhui Wang, Hao Qian, Bo Xiao Rapamycin suppresses the recurrent excitatory circuits of dentate gyrus in a mouse model of temporal lobe epilepsy Biochemical and Biophysical Research Communications, 2012; 420(1): 199–204
17. Rongjing Ge, Hao Qian, Jin-Hui Wang Physiological synaptic signals initiate sequential spikes at soma of cortical pyramidal neurons Molecular Brain, 2011; 4(19)
18. Na Chen, Jiandong Yu, Hao Qian, Rongjing Ge, Jin-Hui Wang Axons Amplify Somatic Incomplete Spikes into Uniform Amplitudes in Mouse Cortical Pyramidal Neurons PLoS One. 2010; 5(7): e11868
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| 专业研究方向：
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| 专业名称 |
研究方向 |
招生类别 |
| 107200生物医学工程 |
01医学基础研究 |
博士学术学位 |
| 071000生物学 |
01生物化学与分子生物学 |
硕士学术学位 |
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