医学院


 
导师代码: 20509
导师姓名: 王晨辉
性    别:
特    称:
青年千人
职    称: 教授
学    位: 理学博士学位
属    性: 专职
电子邮件: wangch @ uestc.edu.cn

学术经历:   2010.11-2015.09 克利夫兰医学中心免疫系 博士后 导师:李晓霞 2007.09-2010.07 军事医学科学院 细胞生物学 博士学位 导师:张学敏 2004.09-2007.07 军事医学科学院 细胞生物学 硕士学位 导师:张学敏

个人简介:   王晨辉,教授,博士生导师。2010年毕业于军事医学科学院张学敏院士实验室,获得细胞生物学博士学位。于2010年11月至2015年9月在美国克利夫兰医学中心李晓霞教授实验室从事博士后研究。实验室目前主要进行免疫治疗研究(抗感染免疫、抗自身免疫疾病和抗肿瘤免疫)。以第一作者或者通讯作者在Nature Immunology,Immunity,Nature Neuroscience,PNAS,Nature Communications,Autophagy, J Immunol, Science Signaling等著名学术期刊发表学术论文20余篇,论文一共引用1200余次。2016年入选中组部青年项目(优先资助)。2017年当选为湖北省免疫学会青年免疫委员会副主任委员。美国免疫学家协会会员(AAI member)。自然科学基金委医学部重大项目、重点项目会评专家。

科研项目:   1) 青年千人经费,优先资助,2017-2020,主持; 2) 国家重点研发计划,“递送载体的体内过程、生物效应及调控机制”,2021.1-2025.12,子课题负责人; 3) 自然科学基金面上项目,“LncRNA-TRAF3IP2-AS1通过调控IL-17信号通路在银屑病中发挥的作用机制研究”,2019.1-2022.12,主持; 4) 武汉市“晨光计划”,2017-2020,主持;

研究成果:   (1) Chen, Jianwen#; He, Ruirui#; Sun, Wanwei*; Gao, Ru; Peng, Qianwen; Zhu, Liwen; Du, Yanyun; Ma, Xiaojian; Guo, Xiaoli; Zhang, Huazhi; Tan, Chengcheng; Wang, Junhan; Zhang, Wei; Weng, Xiufang; Man, Jianghong; Bauer, Hermann; Wang,Qing K.; Martin, Bradley N.; Zhang, Cun-Jin*; Li, Xiaoxia; Wang, Chenhui*; TAGAP instructs Th17 differentiation by bridging Dectin activation to EPHB2 signaling in innate antifungal response, Nature Communications, 2020, 11(1):0-1913. (2) Zhang, Huazhi#; Cui, Zhihui#; Cheng, Du; Du, Yanyun; Guo, Xiaoli; Gao, Ru; Chen, Jianwen; Sun, Wanwei; He, Ruirui; Ma, Xiaojian; Peng, Qianwen;Martin, Bradley N; Yan, Wei; Rong, Yueguang*; Wang, Chenhui*; RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells forthe maintenance of intestinal homeostasis., Autophagy, 2020, Dec(17): 1-18. (3) Wanwei Sun#*, Xiaojian Ma#, Heping Wang, Yanyun Du, Jianwen Chen, Huijun Hu, Ru Gao, Ruirui He, Qianwen Peng, Zhihui Cui, Huazhi Zhang, Junhan Wang, Xinming Jia, Bradley N. Martin, Cun-Jin Zhang*, Xiaoxia Li, Chenhui Wang*;MYO1F regulates anti-fungal immunity by regulating acetylation of microtubules. Proc Natl Acad Sci U S A. 2021 Jul 27;118(30):e2100230118. (4) Du Y#, Shi R#, Zhang Y#, Duan X, Li L, Zhang J, Wang F, Zhang R, Shen H, Wang Y, Wu Z, Peng Q, Pan T, Sun W, Huang W, Feng Y, Feng H, Xiao J, Tan W*, Wang Y*, Wang C*, Yan J*. A broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variants. Nat Commun. 2021 Aug 17;12(1):5000 (co-corresponding author). (5) Wanwei Sun#; Heping Wang#; Huijun Hu; Xiaojian Ma; Huazhi Zhang; Jianwen Chen; Yanyun Du; Ruirui He; Zhihui Cui; Qianwen Peng; Chenhui Wang*; Cutting Edge: EPHB2 is a co-receptor for fungal recognition and phosphorylation of Syk in the dectin-1 signaling pathway, J Immunol. 2021 Apr 1;206(7):1419-1423. (6) Ruirui He#, Songfang Wu#, Ru Gao#, Jianwen Chen, Qianwen Peng, Huijun Hu, Liwen Zhu, Yanyun Du, Wanwei Sun, Xiaojian Ma, Huazhi Zhang, Zhihui Cui, Heping Wang, Bradley N. Martin, Yueying Wang*, Cun-jin Zhang*, Chenhui Wang*; Identification of a LncRNA TRAF3IP2-AS1 as key regulator of IL-17 signaling through the SRSF10-IRF1-Act1 axis in autoimmune diseases. J Immunol. 2021 May 15;206(10):2353-2365. (7) Wang, Chenhui#*; Zhang, Cun-Jin#; Martin, N Bradley#; Bulek, Katarzyna; Kang, Zizhen; Zhao, Junjie; Bian, Guanglin; Carman, Julie A; Gao, Ji; Dongre,Ashok; Xue, Haibo; Miller, Stephen D; Qian, Youcun; Hambardzumyan, Dolores; Hamilton, Tom; Ransohoff, M Richard*; Li, Xiaoxia*; IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression., Nat Commun, 2017, 8: 15508-15508 (co-correspondence author). (8) Martin, N Bradley#; Wang, Chenhui#; Zhang, Cun-jin; Kang, Zizhen; Gulen, Muhammet Fatih; Zepp, Jarod A; Zhao, Junjie; Bian, Guanglin; Do, Jeong-su; Min,Booki; Pavicic, Paul G Jr; El-Sanadi, Caroline; Fox, Paul L; Akitsu, Aoi; Iwakura, Yoichiro; Sarkar, Anasuya; Wewers, Mark D; Kaiser, William J; Mocarski, Edward S; Rothenberg, Marc E; Hise, Amy G; Dubyak, George R; Ransohoff, M Richard*; Li, Xiaoxia*; T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis., Nat Immunol, 2016, 17(5): 583-592 (co-first author). (9) Liu, Zhuo; Zhu, Liwen; Lu, Zhengjuan; Chen, Huiping; Fan, Lizhen; Xue,Qun; Shi, Jianquan; Li, Meiying; Li, Hui; Gong, Jie; Shi, Jingping; Wang, Tao;Jiang, Mei-Ling; Cao, Runjing; Meng, Hailan; Wang, Chenhui; Xu, Yun; Zhang, Cun-Jin*; IL-37 Represses the Autoimmunity in Myasthenia Gravis via Directly Targeting Follicular Th and B Cells, The Journal of Immunology, 2020, 204(7):1736-1745. (10) Zhang Cun-Jin#; Wang, Chenhui#; Jiang Meiling#; Gu Chunfang; Xiao Jianxin; Chen Xing; Martin Bradley N; Tang Fangqiang; Yamamoto Erin; Xian Yibo;Wang Han; Li Fengling; Sartor R Balfour; Smith Howard; Husni M Elaine; Shi Fu-Dong; Gao Ji; Carman Julie; Dongre Ashok; McKarns Susan C; Coppieters Ken; Jorgensen Trine N; Leonard Warren J; Li Xiaoxia; *Act1 is a negative regulator in T and B cells via direct inhibition of STAT3, Nature Communications, 2018,9(1): 0-2745 (co-first author). (11) Cun Jin Zhang#; Meiling Jiang#; Hao Zhou; Weiwei Liu; Chenhui Wang; Zizhen Kang; Bing Han; Quanri Zhang; Xing Chen; Jianxin Xiao; Amanda Fisher;William J Kaiser; Masanori A Murayama; Yoichiro Iwakura; Ji Gao; Julie Carman; Ashok Dongre; George Dubyak; Derek W Abbott; Fu Dong Shi; Richard M Ransohoff*; Xiaoxia Li*; TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation, Journal of Clinical Investigation, 2018, 128(12): 5399-5412. (12) Liu, Caini#; Zhu, Liang#; Fukuda, Koichi; Ouyang, Suidong; Chen, Xing; Wang, Chenhui; Zhang, Cun-Jin; Martin, Bradley; Gu, Chunfang; Qin, Luke; Rachakonda, Suguna; Aronica, Mark; Qin, Jun*; Li, Xiaoxia*; The flavonoid cyanidin blocks binding of the cytokine interleukin-17A to the IL-17RA subunit to alleviate inflammation in vivo., Sci Signal, 2017, 10(467). (13) Wang, Jingjing; Fa, Jingjing; Wang, Pengyun; Jia, Xinzhen; Peng,Huixin; Chen, Jing; Wang, Yifan; Wang, Chenhui; Chen, Qiuyun; Tu, Xin; Wang, K Qing*; Xu, Chengqi*; NINJ2- A novel regulator of endothelial inflammation and activation., Cell Signal, 2017, 35: 231-241. (14) Martin, N Bradley#; Wang, Chenhui#; Willette-Brown, Jami; Herjan, Tomasz; Gulen, F Muhammet; Zhou, Hao; Bulek, Katarzyna; Franchi, Luigi; Sato,Takashi; Alnemri, Emad S; Narla, Goutham; Zhong, Xiao-Ping; Thomas, James; Klinman, Dennis; Fitzgerald, Katherine A; Karin, Michael; Nunez, Gabriel; Dubyak, George; Hu, Yinling*; Li, Xiaoxia*; IKKalpha negatively regulates ASC-dependent inflammasome activation., Nat Commun, 2014, 5: 4977-4977 (co-first author). (15) Wu, Ling#; Wang, Chenhui#; Boisson, Bertrand; Misra, Saurav; Rayman, Patricia; Finke, James H; Puel, Anne; Casanova, Jean-Laurent*; Li, Xiaoxia*; The differential regulation of human ACT1 isoforms by Hsp90 in IL-17 signaling., J Immunol, 2014, 193(4): 1590-1599 (co-first author). (16) Gong, Lin#; Wang, Chenhui#; Huang, Yi Jiao; Liu, Feng; Li, Teng; Dai, Jiang; Li, Ai Ling; Zhou, Tao; Xia, Qing*; Chen, Liang*; CUEDC2 interacts with heat shock protein 70 and negatively regulates its chaperone activity., Biochem Biophys Res Commun, 2014, 447(1): 64-69 (co-first author). (17) Wang, Chenhui#; Wu, Ling#; Bulek, Katarzyna; Martin, Bradley N; Zepp, Jarod A; Kang, Zizhen; Liu, Caini; Herjan, Tomasz; Misra, Saurav; Carman, JulieA; Gao, Ji; Dongre, Ashok; Han, Shujie; Bunting, Kevin D; Ko, Jennifer S; Xiao,Hui; Kuchroo, Vijay K; Ouyang, Wenjun; Li, Xiaoxia*; The psoriasis-associatedD10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90., Nat Immunol, 2013, 14(1): 72-81. (18) Boisson, Bertrand*; Wang, Chenhui; Pedergnana, Vincent; Wu, Ling; Cypowyj, Sophie; Rybojad, Michel; Belkadi, Aziz; Picard, Capucine; Abel,Laurent; Fieschi, Claire; Puel, Anne; Li, Xiaoxia; Casanova, Jean-Laurent*; AnACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis., Immunity, 2013, 39(4): 676-686. (19) Kang, Zizhen; Wang, Chenhui; Zepp, Jarod; Wu, Ling; Sun, Kevin; Zhao,Junjie; Chandrasekharan, Unni; DiCorleto, Paul E; Trapp, Bruce D; Ransohoff, M Richard*; Li, Xiaoxia*; Act1 mediates IL-17-induced EAE pathogenesis selectively in NG2+ glial cells., Nat Neurosci, 2013, 16(10): 1401-1408. (20) Kang, Zizhen; Swaidani, Shadi; Yin, Weiguo; Wang, Chenhui; Barlow,Jillian L; Gulen, Muhammet Fatih; Bulek, Katarzyna; Do, Jeong-su; Aronica, Mark; McKenzie, Andrew N J; Min, Booki; Li, Xiaoxia*; Epithelial cell-specificAct1 adaptor mediates interleukin-25-dependent helminth expulsion through expansion of Lin(-)c-Kit(+) innate cell population., Immunity, 2012, 36(5):821-833. (21) Kang, Zizhen#; Liu, Liping#; Spangler, Roo; Spear, Charles; Wang, Chenhui; Gulen, Muhammet Fatih; Veenstra, Mike; Ouyang, Wenjun; Ransohoff, M Richard*; Li, Xiaoxia*; IL-17-induced Act1-mediated signaling is critical for cuprizone-induced demyelination., J Neurosci, 2012, 32(24): 8284-8292. (22) Liu, Caini#; Swaidani, Shadi#; Qian, Wen; Kang, Zizhen; Sun, Paige; Han, Yue; Wang, Chenhui; Gulen, Muhammet Fatih; Yin, Weiguo; Zhang, Chunjiang;Fox, Paul L; Aronica, Mark; Hamilton, Thomas A; Misra, Saurav; Deng, Junpeng; Li, Xiaoxia*; A CC' loop decoy peptide blocks the interaction between Act1 and IL-17RA to attenuate IL-17- and IL-25-induced inflammation., Sci Signal, 2011, 4(197): ra72-ra72. (23) Zhang, H-Y#; Man, J-H#; Liang, B; Zhou, T; Li, T; Li, H-Y; Wang, C-H; Li, W-H; Jin, B-F; Zhang, P-J; Zhao, J; Pan, X; He, K; Gong, W-L; Zhang, X-M*; Li, A-L*; Tumor-targeted delivery of biologically active TRAIL protein. Cancer Gene Ther, 2010, 17(5): 334-343. (24) Li, Hui-Yan#; Liu, Hui#; Wang, Chen-Hui; Zhang, Ji-Yan; Man, Jiang-Hong; Gao, Yan-Fei; Zhang, Pei-Jing; Li, Wei-Hua; Zhao, Jie; Pan, Xin; Zhou, Tao; Gong, Wei-Li; Li, Ai-Ling*; Zhang, Xue-Min*; Deactivation of the kinase IKK by CUEDC2 through recruitment of the phosphatase PP1., Nat Immunol, 2008, 9(5): 533-541. (25) Zhou, Tao#; Liang, Bing#; Su, Gui-Ying; Gong, Wei-Li; Li, Hui-Yan; Tian, Li-Feng; He, Kun; Zhao, Jie; Man, Jiang-Hong; Li, Tao; Li, Wei-Hua; Zhang, Zhi-Yi; Wang, Chen-Hui; Li, Ai-Ling; Liu, Hui; Pan, Xin; Zhang, Pei-Jing; Jin, Bao-Feng; Zhang, Xue-Min*; Identification of ubiquitin target proteins using cell-based arrays., J Proteome Res, 2007, 6(11): 4397-4406.

专业研究方向:  
专业名称 研究方向 招生类别
107200生物医学工程 01医学基础研究 博士
071000生物学 01生物化学与分子生物学 硕士


学院列表
01  信息与通信工程学院
02  电子科学与工程学院
03  材料与能源学院
04  机械与电气工程学院
05  光电科学与工程学院
06  自动化工程学院
07  资源与环境学院
08  计算机科学与工程学院
09  信息与软件工程学院
10  航空航天学院
11  数学科学学院
12  物理学院
13  医学院
14  生命科学与技术学院
15  经济与管理学院
16  公共管理学院
17  外国语学院
18  马克思主义学院
21  基础与前沿研究院
22  通信抗干扰技术国家级重点实验室
23  电子科学技术研究院
28  深圳高等研究院