医学院
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导师代码: |
20451
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导师姓名: |
周杰
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性 别: |
女 |
特 称: |
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职 称: |
副研究员
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学 位: |
博士学位
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属 性: |
专职 |
电子邮件: |
506468282
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qq.com
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学术经历:
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中国人民解放军陆军军医大学博士
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个人简介:
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肿瘤学博士,博士后,副研究员,硕士生导师。四川省生物信息学学会委员。电子科技大学学术新人奖获得者。主要从事肿瘤放射治疗及免疫治疗相关研究。以第一作者身份在Nature communications, Frontiers in Immunology,World Journal of Gastroenterology 等国际知名期刊上发表多篇SCI论文。文章累积影响因子超过80分。发表国内核心期刊数十篇。主持国家级及省部级项目三项,参与国家级及省部级课题多项。获国家专利一项。
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科研项目:
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(1)国家自然科学青年基金项目:EZH2介导组蛋白甲基化修饰调控MDSC富集在炎症性肠病中的作用及机制研究; 主持
(2)四川省科技厅国际科技创新合作/港澳台科技创新合作项目:不同亚型EB病毒对鼻咽癌患者疗效预测价值探索;主持
(3)重庆市研究生科研创新项目:心肌细胞条件培养液抑瘤活性物质的抗肿瘤作用;主持
(4)国家自然科学青年基金项目:AMT在TCF4调控下介导线粒体甘氨酸代谢促进非小细胞肺癌恶性增殖的机制研究;主要参与者
(5)四川省科技厅国际科技创新合作/港澳台科技创新合作项目:外周 CD8 阳性 T 细胞功能亚群影响弥漫大B 淋巴瘤患者 R-CHOP 治疗预后的细胞分子机制探索;主要参与者
(6)四川省科技厅应用基础研究计划:MiRNA-138 调控腮腺腺泡细胞放射后损伤作用及机制研究;主要参与者
(7)四川省科技厅应用基础研究计划:Traf6/mTOR 双向调控肿瘤相关巨噬细胞极化介导的胶质瘤放疗增敏/抵抗的机制研究;主要参与者
(8)中央高校校级科研项目:免疫通胀在头颈肿瘤放疗的分子机制探索;主要参与者
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研究成果:
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(1) Enhancer of zeste homolog 2 contributes to apoptosis by inactivating janus kinase 2/ signal transducer and activator of transcription signaling in inflammatory bowel disease. World Journal of Gastroenterology, 2021 Jun 14;27(22):3073-3084. (IF: 5.742)
(2)Targeting EZH2 Histone Methyltransferase Activity Alleviates Experimental Intestinal Inflammation. Nature Communications, 2019 Jun 3;10 (1):2427. (IF: 14.919)
(3)Low-Dose Total Body Irradiation Can Enhance Systemic Immune Related Response Induced by Hypo-Fractionated Radiation. Frontiers in Immunology, 2019 Feb 27;10:317. (IF: 7.561)
(4)Programmed Death Ligand 1 Expression and CD8+ Tumor-infiltrating Lymphocyte Density Differences between Paired Primary and Brain Metastatic Lesions in Non-small Cell Lung Cancer. Biochemical and Biophysical Research Communications, 2018;498:751-757. (IF: 3.575)
(5)Control of Intestinal Inflammation, Colitis-Associated Tumorigenesis, and Macrophage Polarization by Fibrinogen-Like Protein 2. Frontiers in Immunology, 2018 Jan 30;9:87. (IF: 7.561)
(6) EZH2 Inhibitor GSK126 Suppresses Antitumor Immunity by Driving Production of Myeloid-derived Suppressor Cells. Cancer Research, 2019 Apr 15;79(8):2009-2020 (IF: 12.701).
(7) Fast model for evaluation of the thyroid dosimetry during chest tumor radiotherapy. Dose-Response, 2019 Nov 22;17(4) (IF: 2.658).
(8) A new marker based on risk stratification of human papillomavirus DNA and tumor size to predict survival of locally advanced cervical cancer. Int J Gynecol Cancer. 2019 Mar; 29(3):459-465 (IF: 3.437).
(9) Clinical outcome and prognostic analysis of young adults nasopharyngeal carcinoma patients of a nonendemic area in intensity-modulated radiotherapy era. Future Oncol, 2019 Feb;15(4):381-389 (IF: 2.279).
(10) TWIST1 up-regulates miR-214 to promote the epithelial-to-mesenchymal transition and metastasis in lung adenocarcinoma. Int J Mol Med, 2018 Jul;42(1):461-470 (IF: 2.928).
(11) Ovarian cancer stem-like cells differentiate into endothelial cells and participate in tumor angiogenesis through autocrine CCL5 signaling. Cancer letter, 2016 Jun 28;376(1):137-47 (IF: 8.679).
(12) In vitro and in vivo studies on the inhibitory effects of myocardial cell culture medium on growth of a human lung adenocarcinoma cell line, A549. Curr Oncol. 2016 Feb;23(1): e35-40 (IF: 3.677).
(13) Synergistic effect of combination topotecan and chronomodulated radiotherapy on xenografted human nasopharyngeal carcinoma. Int J Radiat Oncol Bio Phys, 2013;87(2):356-362 (IF: 7.038).
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专业研究方向:
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专业名称 |
研究方向 |
招生类别 |
100200临床医学 |
07肿瘤学 |
硕士学术学位 |
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