医学院
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| 导师代码： |
20182
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| 导师姓名： |
杨牧
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| 性 别： |
男 |
| 特 称： |
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| 职 称： |
教授
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| 学 位： |
博士学位
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| 属 性： |
专职 |
| 电子邮件： |
mu.yang@uestc.edu.cn
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| 学术经历：
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2012年至2019年供职于加拿大McGill大学附属Montréal Neurological Hospital and Institute。2019年4月至今供职于四川省肿瘤医院，任肿瘤实验研究部主任。
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| 个人简介：
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杨牧，博士，教授，博士研究生导师。主要研究方向：1、记忆通胀介导重大疾病演进的免疫学机制；2、宿主免疫异质性的生物学原理与干预策略。发表论文70余篇，总影响因子约330，单篇最高他引600余次。
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| 科研项目：
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主持加拿大CIHR、Catherine Bushnell Foundation、中央引导地方和四川省国际科技创新合作重大项目等国家和省部级基金9项。
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| 研究成果：
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近五年代表文章：
1. Li Y, Xiao J, Li C, Yang M. Memory inflation: Beyond the acute phase of viral infection. Cell Prolif. 2024 Jul 11:e13705. IF=5.9(中科院1区)
2. Li C, Feng X, Li S, He X, Luo Z, Cheng X, Yao J, Xiao J, Wang X, Wen D, Liu D, Li Y, Zhou H, Ma L, Lin T, Cai X, Lin Y, Guo L, Yang M. Tetrahedral DNA loaded siCCR2 restrains M1 macrophage polarization to ameliorate pulmonary fibrosis in chemoradiation-induced murine model. Mol Ther. 2024 Mar 6;32(3):766-782. IF=12.1(中科院1区)
3. Sun H, Wang D, Ren J, Liu J, Wang Z, Wang X, Zhang A, Yang K, Yang M, Zhou H. Vitamin D ameliorates Aeromonas hydrophila-induced iron-dependent oxidative damage of grass carp splenic macrophages by manipulating Nrf2-mediated antioxidant pathway. Fish Shellfish Immunol. 2023 Nov;142:109145. IF=4.1(中科院2区)
4. He Q, Huang Y, Yuan L, Wang Z, Wang Q, Liu D, Li L, Li X, Cao Z, Wang D, Yang M. A promising predictive biomarker combined EBV NDA with PNI for nasopharyngeal carcinoma in nonendemic area of China. Sci Rep. 2023 Jul 20;13(1):11700. IF=3.8(中科院2区)
5. Shi Z, Wang X, Wang J, Chen H, Du Q, Lang Y, Kong L, Luo W, Qiu Y, Zhang Y, Li C, Wen D, Yao J, Cheng X, Cai L, Lin X, Wang R, Mou Z, Li S, Liu D, Zhou H, Zhou H, Yang M. Granzyme B + CD8 + T cells with terminal differentiated effector signature determine multiple sclerosis progression. J Neuroinflammation. 2023 Jun 2;20(1):138. IF=9.3(中科院1区)
6. Shi Z, Du Q, Wang X, Wang J, Chen H, Lang Y, Kong L, Luo W, Yang M, Zhou H., Granzyme B in circulating CD8+ T cells as a biomarker of immunotherapy effectiveness and disability in neuromyelitis optica spectrum disorders. Front Immunol. 2022 Nov 9;13:1027158. IF=5.7(中科院2区)
7. Wen D, Wang X, Chen R, Li H, Zheng J, Fu W, Zhang T, Yang M, You C, Ma L., Single-Cell RNA Sequencing Reveals the Pathogenic Relevance of Intracranial Atherosclerosis in Blood Blister-Like Aneurysms. Front Immunol. 2022 Jul 8;13:927125. IF=5.7(中科院2区)
8. Wen D, Chen R, Li H, Zheng J, Fu W, Shi Z, You C, Yang M, Ma L., Reduced M2 macrophages and adventitia collagen dampen the structural integrity of blood blister-like aneurysms and induce preoperative rerupture. Cell Prolif. 2022 Feb;55(2):e13175. IF=5.9(中科院1区)
9. Liu X, Yu Z, Wu Y, Shi S, Yao J, Feng X, Wen D, Shi Z, Zhao Z, Li Y, Zhou H, You C, Lin Y, Yang M., The immune regulatory effects of tetrahedral framework nucleic acid on human T cells via the mitogen-activated protein kinase pathway. Cell Prolif. 2021 Aug;54(8):e13084. IF=5.9(中科院1区)
10. Oladiran O, Shi XQ, Yang M, Fournier S, Zhang J., Inhibition of TLR4 signaling protects mice from sensory and motor dysfunction in an animal model of autoimmune peripheral neuropathy. J Neuroinflammation. 2021 Mar 22;18(1):77. IF=9.3(中科院1区)
11. Shi Z, Qiu Y, Zhao Z, Wen D, Chen H, Du Q, Zhang Y, Wang J, Yan C, Yang M, Zhou H., CD8+ T cell subpopulations and pro-inflammatory cytokines in neuromyelitis optica spectrum disorder. Ann Clin Transl Neurol. 2021 Jan;8(1):43-53. IF=4.4(中科院2区)
12. Wen D, Kieran NW, Yang M., Letter by Wen et al Regarding Article, "Pathophysiology of Intracranial Aneurysms: COX-2 Expression, Iron Deposition in Aneurysm Wall, and Correlation With Magnetic Resonance Imaging". Stroke. 2020 Dec;51(12):e367-e368. IF=7.8(中科院1区)
13. Wen D, Xiao Y, Yang M., Letter by Wen et al Regarding Article, "Increased Wall Enhancement During Follow-Up as a Predictor of Subsequent Aneurysmal Growth". Stroke. 2020 Oct;51(10):e293-e294. IF=7.8(中科院1区)
14. Shi Z, Du Q, Chen H, Zhang Y, Qiu Y, Zhao Z, Wang J, Yan C, Zhang Q, Yang M, Zhou H., Effects of immunotherapies and prognostic predictors in neuromyelitis optica spectrum disorder: a prospective cohort study. J Neurol. 2020 Apr;267(4):913-924. IF=4.8(中科院2区)
15. Zhang F, Ren Y, Fu W, Wang Y, Qian J, Tao C, You C, Yang M., Association between neutrophil to lymphocyte ratio and blood glucose level at admission in patients with spontaneous intracerebral hemorrhage. Sci Rep. 2019 Oct 30;9(1):15623. IF=3.8(中科院2区)
16. Wen D, Ma L, Yang M., Letter by Wen et al Regarding Article, "Validation of Wall Enhancement as a New Imaging Biomarker of Unruptured Cerebral Aneurysm". Stroke. 2019 Oct;50(10):e305. IF=7.8(中科院1区)
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| 专业研究方向：
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| 专业名称 |
研究领域/方向 |
招生类别 |
| 107200生物医学工程 |
01医学基础研究 |
博士学术学位 |
| 071000生物学 |
04细胞生物学 |
硕士学术学位 |
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