生命科学与技术学院
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| 导师代码： |
20004
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| 导师姓名： |
李亭亭
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| 性 别： |
女 |
| 特 称： |
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| 职 称： |
副研究员
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| 学 位： |
博士学位
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| 属 性： |
专职 |
| 电子邮件： |
litingting
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uestc.edu.cn
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| 学术经历：
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2019.02至今 特聘副研究员
2016.12-2018.12 University of Texas MD Anderson Cancer Center 联合培养博士
2012.09-2018.12 电子科技大学 生物医学工程 硕博连读
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| 个人简介：
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博士，副研究员。研究聚焦于肿瘤微环境中的力学因素调控肿瘤代谢重编程及线粒体动力学在细胞运动、耐药以及巨噬细胞极化中的作用。在ACS Nano, Nat Commun, Acta Biomater, ACS Appl Mater Interfaces 等国际期刊上发表SCI论文20余篇。长期担任Expert Opin Ther Targets, Mater Sci & Eng C 等国际期刊审稿人。
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| 科研项目：
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1. 3D基质力学微环境通过FAK-YAP/TAZ调控肿瘤耐药性的生物力学机制研究，国家自然基金青年项目 (No.31900940)
2. TRIM21/PFK介导的代谢重编程和线粒体动力学在基质刚度影响肿瘤演进中的功能与调控机制研究 ，国家自然基金面上项目（No.32171309）
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| 研究成果：
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[1] T. T. Li, S. S. Shi, S. Goel, X. Shen, X. X. Xie, Z.Y. Chen, H. X. Zhang, L. Li, S. Li, X. Qin, H. Yang, C. H. Wu, Y. Y. Liu* Recent advancements in mesoporous silica nanoparticles towards therapeutic applications for cancer, Acta biomaterialia, 89 (2019) 1-13.
[2] T. T. Li, X. Shen, Y. Geng, Z.Y. Chen, L. Li, S. Li, H. Yang, C. H. Wu, H. J. Zeng, Y. Y. Liu*. Folate-functionalized magnetic-mesoporous silica nanoparticles for drug/gene codelivery to potentiate the antitumor efficacy. ACS Applied Materials & Interfaces, 2016,8 (22):13748-13758.
[3] T. T. Li, X. Shen, X. X. Xie, Z. Y. Chen, S. Li, X. Qin, H. Yang, C. H. Wu, Y. Y. Liu*. Irinotecan/IR-820 coloaded nanocomposite as a cooperative nanoplatform for combinational therapy of tumor. Nanomedicine(Lond), 2018,13 (6):595-603.
[4] T. T. Li, X. Shen, Y. Chen, C. C. Zhang, J. Yan, H. Yang, C. H. Wu, H. J Zeng, Y. Y. Liu*. Polyetherimide-grafted Fe3O4@SiO2 nanoparticles as theranostic agents for simultaneous VEGF siRNA delivery and magnetic resonance cell imaging. International Journal of Nanomedicine, 2015,10 4279-4291.
[5] J. Zhao, X. Wen, L. Tian, T. T. Li, C. Xu, X. Wen, M.P. Melancon, S. Gupta, B. Shen, W. Peng, C. Li, Irreversible electroporation reverses resistance to immune checkpoint blockade in pancreatic cancer, Nature communications, 10 (2019) 899.
[6] X. Shen, T. T. Li, Z. Chen, X. Xie, H. Zhang, Y. Feng, S. Li, X. Qin, H. Yang, C. Wu, C. Zheng, J. Zhu, F. You, Y. Liu*, NIR-Light-Triggered Anticancer Strategy for Dual-Modality Imaging-Guided Combination Therapy via a Bioinspired Hybrid PLGA Nanoplatform, Molecular pharmaceutics, 16 (2019) 1367-1384.
[7] X. Qin, T. T. Li, S. Li, H. Yang, C. Wu, C. Zheng, F. You, Y. Liu*, The tumor biochemical and biophysical microenvironments synergistically contribute to cancer cell malignancy, Cellular & molecular immunology, (2019).
[8] X. Shen, T. T. Li, Z. Y. Chen, Y. Geng, X. X. Xie, S. Li, H. Yang, C. H. Wu, Y. Y. Liu*. Luminescent/magnetic PLGA-based hybrid nanocomposites: a smart nanocarrier system for targeted codelivery and dual-modality imaging in cancer theranostics. International Journal of Nanomedicine, 2017,12 4299-4322.
[9] Z. F. Gao, T. T. Li, X. L. Xu, Y. Y. Liu, H. Q. Luo, N. B. Li*. Green light-emitting polyepinephrine-based fluorescent organic dots and its application in intracellular metal ions sensing. Biosensors & Bioelectronics, 2016,83 134-141.
[10] M. Wu, T. T. Li, L. Chen, S. Peng,W. Liao, R. Bai,X. Zhao, H. Yang, C. H. Wu, H. J. Zeng, Y. Y. Liu*. Essential oils from Inula japonica and Angelicae dahuricae enhance sensitivity of MCF-7/ADR breast cancer cells to doxorubicin via multiple mechanisms. Journal of Ethnopharmacology,2016,180 18-27.
[11] J. Zhao, Z. Xiao, T. T. Li, H. Chen,Y. Yuan, YA. Wang, CH. Hsiao, D.S.Chow, WW. Overwijk, C. Li*. Stromal modulation reverses primary resistance to immune checkpoint blockade in pancreatic cancer. ACS Nano, 2018, doi: 10.1021/acsnano.8b02481.
[12] H. Yang#, L. W. Deng#, T. T. Li, X. Shen, J. Yan, L. Zuo, C. Wu, Y. Y. Liu*. Multifunctional PLGA nanobubbles as theranostic agents: combining doxorubicin and P-gp siRNA co-delivery into human breast cancer cells and ultrasound cellular imaging. Journal of Biomedical Nanotechnology, 2015,11 (12):2124-2136.
[13] H. Yang#, Y. Li#, T. T. Li, M. Xu, Y. Chen, C. H. Wu, X. T. Dang, Y. Y. Liu*. Multifunctional core/shell nanoparticles cross-linked polyetherimide-folic acid as efficient Notch-1 siRNA carrier for targeted killing of breast cancer. Scientific Reports, 2014,4 7072.
[14] H. Yang, X. Shen, J. Yan, X. X Xie, Z. Y. Chen, T. T. Li, S. Li, X. Qin, C. H. Wu, Y. Y. Liu*. Charge-reversal-functionalized PLGA nanobubbles as theranostic agents for ultrasonic-imaging-guided combination therapy. Biomaterials Science, 2018,6 (9):2426-2439.
[15] H. Yang#, Y. Chen#, Z. Y. Chen, Y. Geng, X. X. Xie, X. Shen, T. T. Li, S. Li, C. H. Wu, Y. Y. Liu*. Chemo-photodynamic combined gene therapy and dual-modal cancer imaging achieved by pH-responsive alginate/chitosan multilayer-modified magnetic mesoporous silica nanocomposites. Biomaterials Science, 2017,5 (5):1001-1013.
[16] Y. Huang, X.J. Zhang, H.H. Mao, T. T. Li, R.L. Zhao, Y.J. Yan, X.F. Pang*, Osteoblastic cell responses and antibacterial efficacy of Cu/Zn co-substituted hydroxyapatite coatings on pure titanium using electrodeposition method, Rsc Adv, 5 (2015) 17076-17086.
[17] L. Li, F. L. Zhao, J. Lu, T. T. Li, H. Yang, C. H. Wu, Y. Y. Liu*. Notch-1 signaling promotes the malignant features of human breast cancer through NF-kappaB activation. PLoS ONE, 2014,9 (4):e95912.
[18] J. Zhao, E. J. Koay, T. T. Li, X. X. Wen, C. Li*. A hindsight reflection on the clinical studies of poly(l-glutamic acid)-paclitaxel. Wiley interdisciplinary reviews-Nanomedicine and Nanobiotechnology, 2018,10 (3):e1497.
[19] H. Yang#, M. Xu#, S. Li, X. Shen, T. T. Li, J. Yan, C. C. Zhang, C. H. Wu, H. J. Zeng, Y. Y. Liu*. Chitosan hybrid nanoparticles as a theranostic platform for targeted doxorubicin/VEGF shRNA co-delivery and dual-modality fluorescence imaging. RSC Advances, 2016, 6 (35):29685-29696.
[20] H. Yang, C. C. Zhang, T. T. Li, X. Shen,Z. Y. Chen, X. X. Xie, S. Li, X. Qin, C. H. Wu, Y. Y. Liu*. Rational design of multifunctional polymeric micelles with stimuli-responsive for imaging-guided combination cancer therapy. Journal of Biomedical Nanotechnology, 2017, 13 (10):1221-1234.
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| 专业研究方向：
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| 专业名称 |
研究方向 |
招生类别 |
| 071000生物学 |
04细胞生物学 |
硕士 |
| 083100生物医学工程 |
08电子科技大学-加拿大麦吉尔大学生物医学工程-神经科学双硕士教育项目 |
硕士 |
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