医学院
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| 导师代码： |
12579
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| 导师姓名： |
何冲
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| 性 别： |
男 |
| 特 称： |
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| 职 称： |
研究员
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| 学 位： |
医学博士学位
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| 属 性： |
专职 |
| 电子邮件： |
herrickhoo@163.com
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| 学术经历：
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主要从事肠黏膜免疫以及神经免疫病理机制研究。主持国家自然科学基金面上、青年项目各1项；主持包括四川省科技计划项目、电子科技大学面向重大需求类项目、四川省人社厅留学归国人员择优资助项目在内等多项课题；作为研究骨干参与国家科技部重点研发计划、国家自然科学基金区域创新联合基金重点项目、四川省青年科技创新研究团队等省部级课题多项；以第一作者或通讯作者身份在Science Translational Medicine, Gastroenterology, Gut, Journal of Neuroinflammation、Mucosal Immunol, J Immunol, J Innate Immun等杂志发表SCI论文数十篇。
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| 个人简介：
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何冲，博士，副研究员，美国得克萨斯州立大学贾维斯顿医学分部访问学者，四川省“天府青城计划”科技菁英、电子科技大学“百人计划”、四川省杰出青年科技人才。
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| 科研项目：
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1)鼠尾草酚调控IBD肠黏膜T细胞免疫应答及肠外神经损伤的机制研究(四川省科技厅杰出青年科技人才项目）
2)肠源性效应辅助性T细胞调节炎症性肠病视网膜损伤的机制研究（国家自然科学基金面上项目）
3)柔性动态眼压监测角膜接触镜的制备及应用研究（电子科技大学中央高校基金项目）
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| 研究成果：
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1)He C*#, Xiu W#, Chen Q#, Peng K#, Zhu X, Wang Z, Xu X, Chen Y, Zhang G, Fu J, Dong Q, Wu X, Li A, Liu D, Gao Y, Wang J, Wang Z, Deng B, Shuai P, Gao C, Chen Y, Yu L, Lu F*. Gut-licensed β7+ CD4+ T cells contribute to progressive retinal ganglion cell damage in glaucoma. Sci Transl Med. 2023 Aug 2;15(707):eadg1656. 共同通讯作者IF:17.96 中科院医学1区
2)Chong He#, Tianming Yu#, Yan Shi, Caiyun Ma, Wenjing Yang, Leilei Fang, Mingming Sun, Wei Wu, Fei Xiao, Feifan Guo, Minhu Chen, Hong Yang, Jiaming Qian, Yingzi Cong*, Zhanju Liu*, MicroRNA301A Promotes Intestinal Inflammation and Colitis-Associated Cancer Development by Inhibiting BTG1. Gastroenterology (2017),152(6),1434-1448.e15. IF: 19.233 中科院医学1区
3)Chong He#, Yan Shi#, Ruijin Wu#, Mingming Sun, Leilei Fang, Wei Wu, Changqin Liu, Maochun Tang, Zhong Li, Ping Wang, Yingzi Cong, Zhanju Liu*, miR-301a promotes intestinal mucosal inflammation through induction of IL-17A and TNF-a in IBD. Gut (2016), 65 (12), 1938-1950. IF: 17.943 中科院医学1区
4)Wei Wu#, Chong He#, Changqin Liu, Anthony T Cao, Xiaochang Xue, Heather L Evans-Marin, Mingming Sun, Leilei Fang, Suxia Yao, Irina V Pinchuk, Don W Powell, Zhanju Liu*, Yingzi Cong*, miR-10a inhibits dendritic cell activation and Th1/Th17 cell immune responses in IBD. Gut (2015), 64 (11), 1755-64. 共同第一作者IF: 17.943 中科院医学1区
5)Yan Shi#, Chong He#, Caiyun Ma, Tianming Yu, Yingzi Cong, Wei Cai*, Zhanju Liu*. Smad nuclear interacting protein 1 (SNIP1) inhibits intestinal inflammation through regulation of epithelial barrier function. Mucosal Immunol (2018), 11 (3), 835-845共同第一作者IF: 7.352 中科院医学1区
6)Mingming Sun#, Chong He#, Yingzi Cong* and Zhanju Liu*. Regulatory immune cells in regulation of intestinal inflammatory response to microbiota. Mucosal Immunol (2015), 8 (5), 969-978共同第一作者IF: 7.352 中科院医学1区
7)He C#, Peng K#, Zhu X#, Wang Z#, Xiu W, Zhang G, Chen Y, Sun C, Xiao X, Liu D, Li A, Gao Y, Wang J, Shuai P, Chen Y, Yu L, Lu F. Th1 cells contribute to retinal ganglion cell loss in glaucoma in a VCAM-1-dependent manner. J Neuroinflammation. 2024 Feb 5;21(1):43. IF: 5.79中科院医学1区
8)Huang X#, Pan Y#, Liu Y#, Zhou Z, Zhang Y, Gao C, He C*. Clinical Utility of the Neutrophil-to-Bilirubin Ratio in the Detection of Disease Activity in Ulcerative Colitis. J Inflamm Res. 2023 Jun 16;16:2549-2559.通讯作者IF:4.631
9)Huang Xijing, Ya Liu, Zhou Zhou, Yan Pan, Yinghui Zhang, Caiping Gao, Chong He. Clinical significance of the C-reactive protein-to-bilirubin ratio in patients with ulcerative colitis. Front Med (Lausanne).2023. 通讯作者IF:5.093
10)Zhou Z#, Zhang Y#, Pan Y, Yang X, Li L, Gao C*, He C*. A Novel Neutrophil-Based Biomarker to Monitor Disease Activity and Predict Response to Infliximab Therapy in Patients With Ulcerative Colitis. Front Med (Lausanne).2022 Apr 27;9:872831. 通讯作者IF:5.093
11)Zhou Z, Zhang Y, Yang X, Pan Y, Li L, Gao C*, He C. Clinical Significance of Novel Neutrophil-Based Biomarkers in the Diagnosis and Prediction of Response to Infliximab Therapy in Crohn's Disease. Front Immunol. 2022 Mar 4;13:865968. 通讯作者IF:7.561
12)Xu X#, Zhang G#, Peng K, Gao Y, Wang J, Gao C, He C*, Lu F*. Carnosol Maintains Intestinal Barrier Function and Mucosal Immune Homeostasis in DSS-Induced Colitis. Front Nutr. 2022 May 24;9:894307. 共同通讯作者IF:6.58
13)He C*#, Zhang G#, Fu J, Zhang R, Li A, Liu D, Li B, Chen Y, Deng B, Chen Y, Shuai P, Lu F*. Clinical Significance of Albumin- and Bilirubin-Based Biomarkers in Glaucoma: A Retrospective Case-Control Study. Oxid Med Cell Longev. 2022 Mar 4;2022:8063651. 共同通讯作者IF:6.54
14)Peng K, Xiao J, Wang J, Song Y, Wu L, Xiu W, Chen Q, Chen Y, Shuai P, He C*, Lu F*. MAdCAM-1 mediates retinal neuron degeneration in experimental colitis through recruiting gut-homing CD4+ T cells. Mucosal Immunol. 2021 Jan;14(1):152-163. 共同通讯作者IF: 7.352
15)Mingming Sun#, Chong He#, Liang Chen#, Wenjing Yang, Wei Wu, Feidi Chen, Anthony T. Cao, Suxia Yao, Sara M. Dann, T. G. Murali Dhar, Luisa Salter-Cid, Qihong Zhao, Zhanju Liu and Yingzi Cong. RORγt Represses IL-10 Production in Th17 Cells To Maintain Their Pathogenicity in Inducing Intestinal Inflammation. J Immunol (2019),202(1),79-92. 共同第一作者IF: 4.718
16)Xue Yang#, Qinyu He#, Zhenzhen Guo, Fei Xiong, Yi Li, Yan Pan, Caiping Gao, Liangping Li*, Chong He*. MicroRNA-425 facilitates pathogenic Th17 cell differentiation by targeting forkhead box O1 (Foxo1) and is associated with inflammatory bowel disease. Biochem Biophys Res Commun (2018),496(2),352-358.共同通讯作者IF: 2.705
17)Wei Wu#, Yang Song#,Chong He#, Changqin Liu, Ruijin Wu, Yingzi Cong*, ZhanjuLiu*. Divalent metal-ion transporter 1 is decreased in intestinal epithelialcells and contributes to the anemia in inflammatory bowel disease. Sci Rep(2015), 5, 16344共同第一作者IF: 4.011
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| 专业研究方向：
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| 专业名称 |
研究领域/方向 |
招生类别 |
| 100200临床医学 |
01内科学 |
硕士学术学位 |
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