医学院


 
导师代码: 11605
导师姓名: 朱献军
性    别:
特    称:
四川省百人计划
职    称: 教授
学    位: 哲学博士学位
属    性: 专职
电子邮件: xjzhu2 @ 126.com; xjzhu@uestc.edu.cn

学术经历:   1997年毕业于北京大学,2000年中国科学院微生物所硕士毕业。2000-2006年在德克萨斯大学奥斯汀分校攻读博士学位,获细胞及分子生物学博士学位。2006年-2010年在美国杰克森实验室从事博士后研究工作。2010-2012年在美国国家卫生研究院从事博士后研究工作。2012年5月起任四川省人民医院研究员。

个人简介:   2012年5月作为四川省人民医院海外杰出引进人才,进入人类疾病基因研究四川省重点实验室工作,组建科研团队,主要研究方向为视网膜变性疾病和退行性神经疾病的分子机制、疾病模型构建、基因诊断和基因治疗。2013年入选四川省海外高层次百人计划。2014年获得四川省杰出青年基金。

科研项目:   目前开展的主要研究课题视网膜疾病基因功能和治疗研究;基因敲除疾病模型构建和基因治疗。2013年起担任电子科技大学临床医学院博士生导师。曾获美国青光眼基金会研究基金资助。2013年入选四川省百人计划,2014年获四川省杰出青年基金资助, 2016年获得四川省青年科技创新团队项目。2015年获得四川省学术带头人后备人选;2018年获得四川省卫计委学术带头人称号;2019年获聘四川省卫生健康领军人才。主持的科研项目:国家重大研究计划973项目(课题骨干)1项、国家自然科学基金委面上项目4项;四川省百人计划项目;四川省杰出青年基金项目。在国际著名专业刊物(包括Nature Genetics, PLoS Genetics, Journal of Cell Science, Genetics in Medicine, Human Molecular Genetics, Development等)发表学术论著50余篇。

研究成果:   2. Sun K, Tian W, Li X, Liu W, Yang Y, Zhu Xianjun. Disease Mutation Study Identifies Critical Residues for Phosphatidylserine Flippase ATP11A. Biomed Res Int. 2020 Jun 2;2020:7342817. doi: 10.1155/2020/7342817. 通讯作者, SCI影响因子2.2 3. Junkai Tan#, Xiaoguang Zhang#, Danli Li, Guo Liu, Yun Wang, Daren Zhang, Xizhen Wang, Wenhong Tian, Xiaoyan Dong, Liang Zhou, Xianjun Zhu*, Xuyang Liu*, Ning Fan*, Mol Ther Methods Clin Dev. 2020 Apr 25;17:894-903. doi: 10.1016/j.omtm.2020.04.014. 并列通讯作者, SCI影响因子4.8 4. Xiong Zhu, Li Xiao, Tian Wanli, Yang Yteming, Sun Kuanxiang, Shuzhen Li*, Zhu Xianjun*, Identification of novel USH2A mutations in patients with autosomal recessive retinitis pigmentosa via targeted next?generation sequencing, Mol Med Rep. 2020 Jul;22(1):193-200. doi: 10.3892/mmr.2020.11087. 通讯作者, SCI影响因子1.4 5. Huijuan Xu#, Chao Qu#, Li Gan, Kuanxiang Sun, Junkai Tan, Xuyang Liu, Zhilin Jiang, Wanli Tian, Wenjing Liu, Shanshan Zhang, Yeming Yang, Li Jiang, Xianjun Zhu*, Lin Zhang*, Deletion of the Impg2 Gene Causes the Degeneration of Rod and Cone Cells in Mice, Hum Mol Genet., 2020 Jun 27;29(10):1624-1634. doi: 10.1093/hmg/ddaa062. 通讯作者, SCI影响因子5.2 6. Zhu X, Sun K, Huang L, Ma S, Hao F, Yang Z, Sundaresan P, Zhu Xianjun. Identification of Novel Mutations in the FZD4 and NDP Genes in Patients with Familial Exudative Vitreoretinopathy in South India. Genet Test Mol Biomarkers. 2020 Feb;24(2):92-98. doi: 10.1089/gtmb.2019.0212. 通讯作者, SCI影响因子1.2 7. Liangyao Xiong#, Lin Zhang#, Yeming Yang, Na Li, Wenjia Lai, Fengchao Wang, Xianjun Zhu*, Tao Wang*, ER complex proteins are required for rhodopsin biosynthesis and photoreceptor survival in Drosophila and mice, Cell Death and Differentiation, 2020 Feb;27(2):646-661. doi: 10.1038/s41418-019-0378-6. Epub 2019 Jul 1. 通讯作者, SCI影响因子8.0 8. Lin Zhang#, Xiang Zhang#, Huijuan Xu, Lulin Huang, Shanshan Zhang, Wenjing Liu, Yeming Yang, Ping Fei, Shujin Li, Mu Yang, Peiquan Zhao*, Xianjun Zhu*, Zhenglin Yang*, Exome sequencing revealed Notch ligand JAG1 as a novel candidate gene for familial exudative vitreoretinopathy, Genet Med. 2020 Jan;22(1):77-84. doi: 10.1038/s41436-019-0571-5. 通讯作者, SCI影响因子8.6 9. Gong B, Zhang H, Huang L, Chen Y, Shi Y, Tam PO, Zhu Xianjun, Huang Y, Lei B, Sundaresan P, Li X, Jiang L, Yang J, Lin Y, Lu F, Chen L, Li Y, Leung CK, Guo X, Zhang S, Huang G, Wu Y, Zhou T, Shuai P, Tham CC, Weisschuh N, Krishnadas SR, Mardin C, Reis A, Yang J, Zhang L, Zhou Y, Wang Z, Qu C, Shaw PX, Pang CP, Sun X, Zhu W, Li DY, Pasutto F, Yang Z, Mutant RAMP2 causes primary open-angle glaucoma via the CRLR-cAMP axis. Genet Med. 2019 Apr 19. doi: 10.1038/s41436-019-0507-0. 通讯作者, SCI影响因子8.6 10. Junkai Tan, Guo Liu, Xianjun Zhu, Zhijian Wu, Ningli Wang, Liang Zhou, Zhang X, Ning Fan, Xuyang Liu. Lentiviral Vector-Mediated Expression of Exoenzyme C3 Transferase Lowers Intraocular Pressure in Monkeys. Mol Ther. 2019 May 9. pii: S1525-0016(19)30214-X. doi: 10.1016/j.ymthe.2019.04.021. [Epub ahead of print] PMID: 31129118. SCI影响因子7.0 11. Yang F, Huang Y, Chen X, Liu L, Liao D, Zhang H, Huang G, Liu W, Zhu Xianjun, Wang W, Lobo CA, Yazdanbakhsh K, An X, Ju Z. Deletion of a flippase subunit Tmem30a in hematopoietic cells impairs mouse fetal liver erythropoiesis. Haematologica. 2019 Oct;104(10):1984-1994. doi: 10.3324/haematol.2018.203992. Epub 2019 Feb 28. 影响因子7.5 12. Shanshan Zhang, Wenjing Liu, Yeming Yang, Kuanxiang Sun, Shujin Li, Huijuan Xu, Mu Yang, Lin Zhang*, Xianjun Zhu*, TMEM30A deficiency in endothelial cells impairs cell proliferation and angiogenesis. J Cell Sci. 2019 Apr 3;132(7). pii: jcs225052. doi: 10.1242/jcs.22505. 通讯作者, SCI影响因子4.4 13. Yeming Yang#, Wenjing Liu#, Kuanxiang Sun, Li Jiang, Xianjun Zhu*, Tmem30a deficiency leads to retinal rod bipolar cell degeneration. Journal of Neurochemisty, 2019 Feb; 148(3):400-412. doi: 10.1111/jnc.14643, 通讯作者, SCI影响因子4.6 14. Yeming Yang, Kuanxiang Sun, Wenjing Liu, Lin Zhang, Kun Peng, Shanshan Zhang, Shujin Li, Mu Yang, Zhilin Jiang, Fang Lu, Xianjun Zhu*, Disruption of Tmem30a results in cerebellar ataxia and degeneration of Purkinje cells. Cell Death & Disease, 2018 Sep 5; 9(9):899. doi: 10.1038/s41419-018-0938-6. 通讯作者, SCI影响因子5.6 15. Tan J, Fan N, Wang N, Feng B, Yang M, Liu G, Wang Y, Zhu Xianjun, Kaufman PL, Pang IH, Liu X. Invest Ophthalmol Vis Sci. 2018 Oct 1;59(12):4937-4944. doi: 10.1167/iovs.18-24978. 16. Lin Zhang#, Zixi Sun#, Peiquan Zhao#, Lulin Huang, Mingchun Xu, Yeming Yang, Xue Chen, Fang Lu, Xiang Zhang, Hui Wang, Shanshan Zhang, Wenjing Liu, Zhilin Jiang, Shi Ma, Rui Chen, Chen Zhao, Zhenglin Yang*, Ruifang Sui*, Xianjun Zhu*, Whole exome sequencing revealed HKDC1 as a candidate gene associated with autosomal-recessive retinitis pigmentosa, Human Molecular Genetics, ddy281, https://doi.org/10.1093/hmg/ddy281, Published: 31 July 2018, 通讯作者, SCI影响因子4.9 17. Xie D#, Peng K#, Yi Q, Liu W, Yang Y, Sun K, Zhu Xianjun*, Lu F*. Targeted Next Generation Sequencing Revealed Novel PRPF31 Mutations in Autosomal Dominant Retinitis Pigmentosa. Genet Test Mol Biomarkers. 2018 Jun 29。doi: 10.1089/gtmb.2018.0036. (SCI, IF=1.3) #并列通讯作者. 18. Zhou Y#, Li S#, Huang L, Yang Y, Zhang L, Yang M, Liu W, Ramasamy K, Jiang Z, Sundaresan P, Zhu Xianjun*, Yang Z*, A splicing mutation in Aryl Hydrocarbon Receptor associated with retinitis pigmentosa. Human Molecular Genetics, Vol 27, No. 14, 2563–2572. 2018 May 02 DOI:10.1093/hmg/ddy165, 并列通讯作者, SCI影响因子4.9 19. Ning Li#, Yeming Yang,# Cailing Liang, Qiang Qiu, Cong Pan, Mengyuan Li, Shengyong Yang, Lijuan Chen, Xianjun Zhu*, Yiguo Hu*,Tmem30a plays critical roles in ensuring the survival of hematopoietic cells and leukemia cells in mice,American Journal of Pathology, 2018 Jun;188(6):1457-1468. doi: 10.1016/j.ajpath.2018.02.015. Epub 2018 Mar 21. PMID: 29574182并列通讯作者,SCI影响因子4.0 20. Liu X, Wu Y, Miao Z, Zhang H, Gong B, Zhu Xianjun, Huang L, Shi Y, Hao F, Ma S, Lin H, Wang L, Yang Z. A novel deletion downstream of the PAX6 gene identified in a Chinese family with congenital aniridia. Ophthalmic Genet. 2018 Aug; 39(4):428-436. doi: 10.1080/13816810.2018.1466336. Epub 2018 Jun 14. PMID: 29902091。 SCI影响因子1.2 21. Zhang S, Li J, Li S, Yang Y, Yang M, Yang Z, Zhu Xianjun*, Zhang L*. Targeted next-generation sequencing reveals that a compound heterozygous mutation in phosphodiesterase 6a gene leads to retinitis pigmentosa in a Chinese family. Ophthalmic Genet. 2018 Apr 25: 2018 Aug;39(4):487-491. doi: 10.1080/13816810.2018.1461912., SCI影响因子1.2 22. Yang M#, Li S#, Liu W, Yang Y, Zhang L, Zhang S, Jiang Z, Yang Z*, Zhu Xianjun*, Targeted Next-Generation Sequencing Reveals a Novel Frameshift Mutation in the MERTK Gene in a Chinese Family with Retinitis Pigmentosa. Genet Test Mol Biomarkers,2018 Mar;22(3):165-169. (SCI, IF=1.3) #通讯作者. 23. Li S#, Yang M#, Liu W, Liu Y, Zhang L, Yang Y, Sundaresan P, Yang Z, Zhu Xianjun*, Targeted Next-Generation Sequencing Reveals Novel RP1 Mutations in Autosomal Recessive Retinitis Pigmentosa, Genet Test Mol Biomarkers 2018 Feb;22(2):109-114. (SCI, IF=1.3) #通讯作者 24. Liu L#, Zhang L#, Zhang L, Yang F, Zhu X, Lu Z, Yang Y, Lu H, Feng L, Wang Z, Chen H, Yan S, Wang L, Ju Z, Jin H*, Zhu Xianjun*. Hepatic Tmem30a Deficiency Causes Intrahepatic Cholestasis by Impairing Expression and Localization of Bile Salt Transporters. Am J Pathol. 2017 Dec;187(12):2775-2787. doi: 10.1016/j.ajpath.2017.08.01. 通讯作者,SCI影响因子4.0 25. Jeffrey M. Harder, Catherine E. Braine, Pete A. Williams, Xianjun Zhu, Katharine H. MacNicoll, Gregory L. Sousa, Rebecca A. Buchanan, Richard S. Smith, Richard T. Libby, Gareth R. Howell, and Simon W. M. John, Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective. Proc Natl Acad Sci U S A. 2017 May 9;114(19):E3839-E3848. doi: 10.1073/pnas.1608769114. Epub 2017 Apr 26. 26. Outeda P, Menezes L, Hartung EA, Bridges S, Zhou F, Zhu Xianjun, Xu H, Huang Q, Yao Q, Qian F, Germino GG, Watnick T. A novel model of autosomal recessive polycystic kidney questions the role of the fibrocystin C-terminus in disease mechanism. Kidney Int. 2017 Nov;92(5):1130-1144. doi: 10.1016/j.kint.2017.04.027. Epub 2017 Jul 18. 27. Lin Zhang#, Yeming Yang#, Shujin Li, Shanshan Zhang, Xiong Zhu, Zhengfu Tai, Mu Yang, Yuqing Liu, Xinzheng Guo, Bo Chen, Zhilin Jiang, Fang Lu*, Xianjun Zhu*, Loss of Tmem30a leads to photoreceptor degeneration, Sci Rep. 2017; 7: 9296. Published online 2017 Aug 24. doi: 10.1038/s41598-017-09506-5, 通讯作者,影响因子4.3 28. Yang Yeming#, Zhang Lin#, Li Shujin, Zhu Xianjun*, and Sundaresan Periasamy*. Candidate Gene Analysis Identifies Mutations in CYP1B1 and LTBP2 in Indian Families with Primary Congenital Glaucoma. Genetic Testing and Molecular Biomarkers. April 2017, 21(4): 252-258. (SCI, IF=1.3) #通讯作者 29. Yang Y#, Yang Y#, Huang L, Zhai Y, Li J, Jiang Z, Gong B, Fang H, Kim R, Yang Z, Sundaresan P, Zhu Xianjun*, Zhou Y*. Whole exome sequencing identified novel CRB1 mutations in Chinese and Indian populations with autosomal recessive retinitis pigmentosa. Sci Rep. 2016 Sep 27;6:33681. doi: 10.1038/srep33681. #通讯作者 (SCI 5.7) 30. Zhang L, Yang Y, Li S, Tai Z, Huang L, Liu Y, Zhu X, Di Y, Qu C, Jiang Z, Li Y, Zhang G, Kim R, Sundaresan P, Yang Z*, Zhu Xianjun*. Whole Exome Sequencing Analysis Identifies Mutations in LRP5 in Indian Families with Familial Exudative Vitreoretinopathy. Genet Test Mol Biomarkers. 2016 Jul;20(7):346-51. #通讯作者 (SCI 1.3 ) 31. Huang L, Zhang H, Cheng CY, Wen F, Tam PO, Zhao P, Chen H, Li Z, Chen L, Tai Z, Yamashiro K, Deng S, Zhu Xianjun, Chen W, Cai L, Lu F, Li Y, Cheung CM, Shi Y, Miyake M, Lin Y, Gong B, Liu X, Sim KS, Yang J, Mori K, Zhang X, Cackett PD, Tsujikawa M, Nishida K, Hao F, Ma S, Lin H, Cheng J, Fei P, Lai TY, Tang S, Laude A, Inoue S, Yeo IY, Sakurada Y, Zhou Y, Iijima H, Honda S, Lei C, Zhang L, Zheng H, Jiang D, Zhu X, Wong TY, Khor CC, Pang CP, Yoshimura N, Yang Z. A missense variant in FGD6 confers increased risk of polypoidal choroidal vasculopathy. Nat Genet. 2016 Jun;48(6):640-7. doi: 10.1038/ng.3546. Epub 2016 Apr 18. 32. Yu Zhou#, Bibhuti Ballav Saikia#, Zhilin Jiang, Xiong Zhu, Lulin Huang, Ramasamy Kim, Yin Yang, Chao Qu, Fang Hao, Bo Gong, Zhengfu Tai, Lihong Niu, Zhenglin Yang, Periasamy Sundaresan*, Xianjun Zhu*, Whole exome sequencing reveals a novel frame shift mutation in the FAM161A gene causing autosomal recessive retinitis pigmentosa in the Indian population. Journal of Human Genetics, 2015, Oct;60(10):625-30. #通讯作者 33. Xinzheng Guo, Shao-Bin Wang, Hongping Xu, Adema Ribic, Ethan Mohns, Yu Zhou, Xianjun Zhu, Thomas Biederer, Michael Crair, and Bo Chen, A Short N-terminal Domain of HDAC4 Preserves Photoreceptors and Restores Visual Function in Retinitis Pigmentosa, Nature Communications, 2015 Aug 14;6:8005. 34. Chen Y, Lin Y, Vithana EN, Jia L, Zuo X, Wong TY, Chen LJ, Zhu Xianjun, Tam PO, Gong B, Qian S, Li Z, Liu X, Mani B, Luo Q, Guzman C, Leung CK, Li X, Cao W, Yang Q, Tham CC, Cheng Y, Zhang X, Wang N, Aung T, Khor CC, Pang CP, Sun X, Yang Z. Common variants near ABCA1 and in PMM2 are associated with primary open-angle glaucoma. Nat Genet. 2014 Oct;46(10):1115-9. doi: 10.1038/ng.3078. 35. Coleman JA#, Xianjun Zhu#, Djajadi HR, Molday LL, Smith RS, Libby RT, John SW*, Molday RS*. Phospholipid flippase ATP8A2 is required for normal visual and auditory function and photoreceptor and spiral ganglion cell survival. J Cell Sci. 2014 March 1, 127, 1138-1149. (SCI, IF=5.9).#并列第一作者

专业研究方向:  
专业名称 研究方向 招生类别
107200生物医学工程 01医学基础研究 博士
071000生物学 01生物化学与分子生物学 硕士


学院列表
01  信息与通信工程学院
02  电子科学与工程学院
03  材料与能源学院
04  机械与电气工程学院
05  光电科学与工程学院
06  自动化工程学院
07  资源与环境学院
08  计算机科学与工程学院
09  信息与软件工程学院
10  航空航天学院
11  数学科学学院
12  物理学院
13  医学院
14  生命科学与技术学院
15  经济与管理学院
16  公共管理学院
17  外国语学院
18  马克思主义学院
21  基础与前沿研究院
22  通信抗干扰技术国家级重点实验室
23  电子科学技术研究院
28  深圳高等研究院