导师个人信息 - 电子科大研招网

生命科学与技术学院

导师代码：	10460
导师姓名：	周红
性别：	男
特称：
职称：	教授
学位：	哲学博士学位
属性：	专职
电子邮件：	zhouhongzh@uestc.edu.cn

学术经历：

1987年毕业于四川大学化学系有机化学专业，获理学学士学位。1990年毕业于四川大学生物系生物化学专业，获理学硕士学位，同年留校任教，1995年晋升为副教授；2003年在香港大学动物系获理学博士学位；2003年至2004年在加拿大约克大学生物系完成博士后工作；2005年至今，在电子科技大学生命科学与技术学院工作，教授，博士生导师。

个人简介：

入选教育部新世纪优秀人才支持计划和四川省学术和技术带头人。2010年至今担任中国生物化学与分子生物学学会理事，2005年至今担任四川省生物化学与分子生物学学会理事。长期受邀担任Gen Comp Endocrinol, Fish Shellfish Immunol，Vet Immunol Immunopathol，European Journal of Histochemistry和Fish Physiol Biochem等期刊审稿人。在国内外学术刊物上发表论文70余篇，包括Endocrinology，Dev Comp Immunol，Mol Immunol，Gen Comp Endocrinol, Fish Shellfish Immunol和PLoS One等期刊。学术兴趣主要是围绕鱼类生长和免疫调节活动，阐明相关激素和细胞因子的合成、分泌和作用机制, 代表性工作包括：① 鉴定多种参与硬骨鱼免疫调节的细胞因子的分子结构、表达特征和功能地位，阐明参与的激酶受体、细胞信号通路和转录因子，着重揭示细胞因子相互作用的分子机制和生理意义。特别地，在硬骨鱼中发现细胞因子TGF-β1的双向免疫调节作用，表现在细胞活性、效应分子和淋巴细胞标志分子等不同层面，并通过下调其丝氨酸/苏氨酸激酶受体的表达限制TGF-β1活性信号的放大，为揭示硬骨鱼的免疫调节机制提供了新内容。② 新发现硬骨鱼生长激素（GH）在垂体内以自分泌/旁分泌形式维持其自身的合成与分泌，这一“正反馈”调控机制改变了GH垂体内负反馈调控的传统认识。同时建立了垂体细胞间的反馈调节新模型，全新诠释了促生长轴和促性腺轴的相互关系。成果合理解释了鱼类垂体内GH分泌细胞和促性腺激素分泌细胞间的解剖学关系，特别是提供了硬骨鱼GH合成和分泌的新机制。

科研项目：

1) TGF-?1双向调节硬骨鱼外周血淋巴细胞活性机理的研究（30972280），国家自然科学基金 2) 鱼用基因工程免疫刺激剂和疫苗增强剂的研制及其免疫机制的研究（2011FZ0007），四川省科技支撑计划 3) 草鱼免疫防御因子的功能定位及其应用研究（2012FZ0002），四川省科技支撑计划 4) 硬骨鱼激活素和转化生长因子的生理功能研究（NCEF-06-0814），教育部新世纪优秀人才支持计划 5) 草鱼垂体中激活素对生长激素基因表达的调控：功能意义、分子机理和信号通路（30650003），国家自然科学基金 6) ALK-7及其异构体在肿瘤早期诊断和治疗中的应用（2007SGY003），四川省科技攻关项目 7) 藏药唐古特青兰抗肿瘤活性的研究（2007A04），四川省中医药管理局项目 8) 藏药唐古特青兰抗脑缺血有效部位的分离鉴定（200639），四川省中医药管理局项目 9) 草鱼垂体腺苷酸环化酶激活多肽的研究（05NG002-004），四川省科技攻关项目

研究成果：

1) Du L, Qin L, Wang X, Zhang A, Wei H, Zhou H＊. Characterization of grass carp (Ctenopharyngodon idella) IL-17D: Molecular cloning, functional implication and signal transduction. Dev Comp Immunol. 2014; 42:220-228. 2) Yang K, Zhang S, Chen D, Zhang A, Wang X, Zhou H＊. IFN-γ-activated lymphocytes boost nitric oxide production in grass carp monocytes/macrophages. Fish Shellfish Immunol. 2013; 35(5):1635-1641. 3) Yang X, Wang S, Du L, Yang K, Wang X, Zhang A, Zhou H＊. Molecular and functional characterization of IL-1 receptor type 2 in grass carp: A potent inhibitor of IL-1β signaling in head kidney leukocytes. Dev Comp Immunol. 2013; 41(4):738-745. 4) Wei H, Yang M, Zhao T, Wang X, Zhou H＊. Functional expression and characterization of grass carp IL-10: An essential mediator of TGF-?1 immune regulation in peripheral blood lymphocytes. Mol. Immunol. 2013; 53(4):313-320. 5) Wang X, Wei H, Zhao T, Zhu X, Yang X, Chen D, Zhou H＊. Evidence for pituitary adenylate cyclase-activating peptide as a direct immunoregulator in teleost head kidney. Fish Shellfish Immunol. 2013; 34(1):265-72 6) Zhang A, Chen D, Wei H, Du L, Zhao T, Wang X, Zhou H＊. Functional characterization of TNF-? in grass carp head kidney leukocytes: Induction and involvement in the regulation of NF-?B signaling. Fish and Shellfish Immunol. 2012; 33(5):1123-32 7) Yang M, Wei H, Zhao T, Wang X, Zhang A, Zhou H＊. Characterization of Foxp3 gene from grass carp (Ctenopharyngodon idellus): A rapamycin-inducible transcription factor in teleost immune system. Dev Comp Immunol. 2012; 38: 98-107 8) Du L, Yang X, Yang L, Wang X, Zhang A, Zhou H＊. Molecular evidence for the involvement of RORα and RORγ in immune response in teleost. Fish Shellfish Immunol. 2012; 33: 418-426 9) Yang M, Wang X, Chen D, Wang Y, Zhang A, Zhou H＊. TGF-β1 exerts opposing effects on grass carp leukocytes: implication in teleost immunity, receptor signaling and potential self-regulatory mechanisms. PLoS One. 2012; 7(4):e35011. 10) Zhao T, Wang X, Wei H, Yang M, Zeng F, Zhou H＊. Molecular and functional characterization of grass carp squint/nodal-related 1: a potential regulator of activin signaling in teleost pituitary cells. Domest Anim Endocrinol. 2012; 42(4):239-48. 11) Zeng F, Xu G, Zhou T, Yang C, Wang X, Peng C, Zhou H＊. Reduced expression of activin receptor-like kinase 7 in breast cancer is associated with tumor progression. Medical Oncology. 2012; 29:2519-2526. 12) Wang X, Zhao T, Wei H, Zhou H＊. Regulation of dopamine D2 receptor expression in grass carp pituitary cells: a possible mechanism for dopaminergic modification of luteinizing hormone synthesis. Gen Comp Endocrinol. 2011; 173(1):48-55. 13) Zhang A, Zhou X, Wang X, Zhou H＊. Characterization of two heat shock proteins (Hsp70/Hsc70) from grass carp (Ctenopharyngodon idellus): Evidence for their differential gene expression, protein synthesis and secretion in LPS-challenged peripheral blood lymphocytes. Comp Biochem Physiol B. 2011; 159(2):109-14 14) Xu JX, Yang M, Deng KJ, Zhou H＊. Antioxidant Activities of Dracocephalum Tanguticum Maxim Extract and Its Up-regulation on the Expression of Neurotrophic Factors in a Rat Model of Permanent Focal Cerebral Ischemia. Am J Chin Med. 2011; 39(1): 65-81 15) Wang X, Xu J, Yang M, Zhou H＊. Chloroform extract of Tibetan herbal medicine Dracocephalum tanguticum Maxim inhibits proliferation of T98G glioblastomas cells by modulating caspase-3 cleavage and expression of Bax and p21. J Med Plant Res. 2011; 5(25): 6024–6031 16) Wang X, Wang Y, Yang M, Zhou H＊. A newly identified epithelial cell adhesion molecule (EpCAM) from grass carp (Ctenopharyngodon idellus): cloning, tissue distribution and lipopolysaccharide-induced expression in head kidney lymphocytes. Fish and Shellfish Immunol. 2010; 29(6):998-1002 17) Yang M, Wang Y, Wang X, Chen C, Zhou H＊. Characterization of grass carp (Ctenopharyngodon idellus) Foxp1a/1b/2: evidence for their involvement in the activation of peripheral blood lymphocyte subpopulations. Fish Shellfish Immunol. 2010; 28：289-295 18) Song C, Wang X, Zhou H＊. Molecular cloning of activin type I and type II receptors and differential regulation of their expression by activin in grass carp pituitary cells. Gen Comp Endocrinol. 2010; 166:211-216. 19) Chen C, Song C, Wang X, Zhou H＊. Molecular cloning, characterization and tissue distribution of six splice variants of activin type IIA receptor (ActRIIA) from grass carp (Ctenopharyngodon idellus). Genes & Genetic Systems. 2009; 84:335-344. 20) Zhou H, Fu G, Yu H, Peng C. Transforming growth factor-beta inhibits aromatase gene transcription in human trophoblast cells via the Smad2 signaling pathway. Reprod Biol Endocrin. 2009; 7:146-155. 21) Zhou L, Yang M, Zhou H, Zhang J, Li K, Xiang Y, Wang N, Tian Y, Yu X. Novel Reticular Cyclen-Based Polymer as Gene Vector in DNA Transfection. Chem Biol Drug Des. 2009; 73(2): 216-224. 22) Wang Z, Yang M, Wang X, Zhou H＊. High-level expression, purification, and characterization of the recombinant grass carp pituitary adenylate cyclase-activating polypeptide (PACAP). Biosci. Biotechnol. Biochem. 2008; 72(6):1550-7. 23) Yang M and Zhou H＊. Grass carp transforming growth factor-?1 (TGF-?1): Molecular cloning, tissue distribution and immunobiological activity in teleost peripheral blood lymphocytes. Mol Immunol. 2008; 45(6): 1792–1798. 24) Sze KH, Zhou H, Yang Y, He M, Jiang Y, Wong AO. Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) as a Growth Hormone (GH)-Releasing Factor in Grass Carp: II. Solution Structure of a Brain-Specific PACAP by Nuclear Magnetic Resonance Spectroscopy and Functional Studies on GH Release and Gene Expression. Endocrinology. 2007; 148(10):5042-59. 25) Xu G， Zhou H， Wang Q， Auersperg N，Peng C. Activin receptor-like kinase 7 induces apoptosis through up-regulation of Bax and down-regulation of Xiap in normal and malignant ovarian epithelial cell lines. Mol Cancer Res. 2006; 4(4):235-46. 26) Wang AO, Zhou H, Jiang Y, Ko WK. Feedback regulation of growth hormone synthesis and secretion in fish and the emerging concept of intrapituitary feedback loop. Comp Biochem Physiol A Mol Integr Physiol. 2006; 144：284-305. 27) Zhou H, Jiang Y, Ko WK, Li W, Wong AO. Paracrine Regulation of Growth Hormone Gene Expression by Gonadotropin Release in Grass Carp Pituitary Cells: Functional Implications, Molecular Mechanisms, and Signal Transduction. Journal of Mol Endocrinol. 2005; 34(2): 415-432. 28) Wong AO, Li W, Leung CY, Huo L, Zhou H. Pituitary adenylate cyclase-activating polypeptide (PACAP) as a growth hormone (GH)-releasing factor in grass carp. I. Functional coupling of cyclic adenosine 3',5'-monophosphate and Ca2+/calmodulin-dependent signaling pathways in PACAP-induced GH secretion and GH gene expression in grass carp pituitary cells. Endocrinology. 2005; 146(12):5407-24. 29) Zhou H, Ko WK, Ho WK, Stojilkovic SS, Wong AO. Novel Aspects of Growth Hormone Autoregulation: Growth Hormone-Induced Growth Hormone Gene Expression in Grass Carp Pituitary Cells through Autocrine/Paracrine Mechanisms. Endocrinology 2004; 145(10): 4615-4628. 30) Zhou H, Wang X, Ko WK, Wong AO. Evidence for a Novel Intrapituitary Autocrine/Paracrine Feedback Loop Regulating Growth Hormone Synthesis and Secretion in Grass Carp Pituitary Cells by Functional Interactions between Gonadotrophs and Somatotrophs. Endocrinology 2004; 145(12)：5548-5559.

专业研究方向：