生命科学与技术学院
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导师代码: |
10460
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导师姓名: |
周红
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性 别: |
男 |
特 称: |
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职 称: |
教授
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学 位: |
哲学博士学位
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属 性: |
专职 |
电子邮件: |
zhouhongzh@uestc.edu.cn
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学术经历:
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1987年毕业于四川大学化学系有机化学专业,获理学学士学位。1990年毕业于四川大学生物系生物化学专业,获理学硕士学位,同年留校任教,1995年晋升为副教授;2003年在香港大学动物系获理学博士学位;2003年至2004年在加拿大约克大学生物系完成博士后工作;2005年至今,在电子科技大学生命科学与技术学院工作,教授,博士生导师。
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个人简介:
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入选教育部新世纪优秀人才支持计划和四川省学术和技术带头人。2010年至今担任中国生物化学与分子生物学学会理事,2005年至今担任四川省生物化学与分子生物学学会理事。长期受邀担任Gen Comp Endocrinol, Fish Shellfish Immunol,Vet Immunol Immunopathol,European Journal of Histochemistry和Fish Physiol Biochem等期刊审稿人。在国内外学术刊物上发表论文70余篇,包括Endocrinology,Dev Comp Immunol,Mol Immunol,Gen Comp Endocrinol, Fish Shellfish Immunol和PLoS One等期刊。学术兴趣主要是围绕鱼类生长和免疫调节活动,阐明相关激素和细胞因子的合成、分泌和作用机制, 代表性工作包括:① 鉴定多种参与硬骨鱼免疫调节的细胞因子的分子结构、表达特征和功能地位,阐明参与的激酶受体、细胞信号通路和转录因子,着重揭示细胞因子相互作用的分子机制和生理意义。特别地,在硬骨鱼中发现细胞因子TGF-β1的双向免疫调节作用,表现在细胞活性、效应分子和淋巴细胞标志分子等不同层面,并通过下调其丝氨酸/苏氨酸激酶受体的表达限制TGF-β1活性信号的放大,为揭示硬骨鱼的免疫调节机制提供了新内容。② 新发现硬骨鱼生长激素(GH)在垂体内以自分泌/旁分泌形式维持其自身的合成与分泌,这一“正反馈”调控机制改变了GH垂体内负反馈调控的传统认识。同时建立了垂体细胞间的反馈调节新模型,全新诠释了促生长轴和促性腺轴的相互关系。成果合理解释了鱼类垂体内GH分泌细胞和促性腺激素分泌细胞间的解剖学关系,特别是提供了硬骨鱼GH合成和分泌的新机制。
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科研项目:
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1) TGF-?1双向调节硬骨鱼外周血淋巴细胞活性机理的研究 (30972280),国家自然科学基金
2) 鱼用基因工程免疫刺激剂和疫苗增强剂的研制及其免疫机制的研究(2011FZ0007),四川省科技支撑计划
3) 草鱼免疫防御因子的功能定位及其应用研究(2012FZ0002),四川省科技支撑计划
4) 硬骨鱼激活素和转化生长因子的生理功能研究(NCEF-06-0814),教育部新世纪优秀人才支持计划
5) 草鱼垂体中激活素对生长激素基因表达的调控:功能意义、分子机理和信号通路(30650003),国家自然科学基金
6) ALK-7及其异构体在肿瘤早期诊断和治疗中的应用(2007SGY003),四川省科技攻关项目
7) 藏药唐古特青兰抗肿瘤活性的研究(2007A04),四川省中医药管理局项目
8) 藏药唐古特青兰抗脑缺血有效部位的分离鉴定(200639),四川省中医药管理局项目
9) 草鱼垂体腺苷酸环化酶激活多肽的研究(05NG002-004),四川省科技攻关项目
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研究成果:
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1) Du L, Qin L, Wang X, Zhang A, Wei H, Zhou H*. Characterization of grass carp (Ctenopharyngodon idella) IL-17D: Molecular cloning, functional implication and signal transduction. Dev Comp Immunol. 2014; 42:220-228.
2) Yang K, Zhang S, Chen D, Zhang A, Wang X, Zhou H*. IFN-γ-activated lymphocytes boost nitric oxide production in grass carp monocytes/macrophages. Fish Shellfish Immunol. 2013; 35(5):1635-1641.
3) Yang X, Wang S, Du L, Yang K, Wang X, Zhang A, Zhou H*. Molecular and functional characterization of IL-1 receptor type 2 in grass carp: A potent inhibitor of IL-1β signaling in head kidney leukocytes. Dev Comp Immunol. 2013; 41(4):738-745.
4) Wei H, Yang M, Zhao T, Wang X, Zhou H*. Functional expression and characterization of grass carp IL-10: An essential mediator of TGF-?1 immune regulation in peripheral blood lymphocytes. Mol. Immunol. 2013; 53(4):313-320.
5) Wang X, Wei H, Zhao T, Zhu X, Yang X, Chen D, Zhou H*. Evidence for pituitary adenylate cyclase-activating peptide as a direct immunoregulator in teleost head kidney. Fish Shellfish Immunol. 2013; 34(1):265-72
6) Zhang A, Chen D, Wei H, Du L, Zhao T, Wang X, Zhou H*. Functional characterization of TNF-? in grass carp head kidney leukocytes: Induction and involvement in the regulation of NF-?B signaling. Fish and Shellfish Immunol. 2012; 33(5):1123-32
7) Yang M, Wei H, Zhao T, Wang X, Zhang A, Zhou H*. Characterization of Foxp3 gene from grass carp (Ctenopharyngodon idellus): A rapamycin-inducible transcription factor in teleost immune system. Dev Comp Immunol. 2012; 38: 98-107
8) Du L, Yang X, Yang L, Wang X, Zhang A, Zhou H*. Molecular evidence for the involvement of RORα and RORγ in immune response in teleost. Fish Shellfish Immunol. 2012; 33: 418-426
9) Yang M, Wang X, Chen D, Wang Y, Zhang A, Zhou H*. TGF-β1 exerts opposing effects on grass carp leukocytes: implication in teleost immunity, receptor signaling and potential self-regulatory mechanisms. PLoS One. 2012; 7(4):e35011.
10) Zhao T, Wang X, Wei H, Yang M, Zeng F, Zhou H*. Molecular and functional characterization of grass carp squint/nodal-related 1: a potential regulator of activin signaling in teleost pituitary cells. Domest Anim Endocrinol. 2012; 42(4):239-48.
11) Zeng F, Xu G, Zhou T, Yang C, Wang X, Peng C, Zhou H*. Reduced expression of activin receptor-like kinase 7 in breast cancer is associated with tumor progression. Medical Oncology. 2012; 29:2519-2526.
12) Wang X, Zhao T, Wei H, Zhou H*. Regulation of dopamine D2 receptor expression in grass carp pituitary cells: a possible mechanism for dopaminergic modification of luteinizing hormone synthesis. Gen Comp Endocrinol. 2011; 173(1):48-55.
13) Zhang A, Zhou X, Wang X, Zhou H*. Characterization of two heat shock proteins (Hsp70/Hsc70) from grass carp (Ctenopharyngodon idellus): Evidence for their differential gene expression, protein synthesis and secretion in LPS-challenged peripheral blood lymphocytes. Comp Biochem Physiol B. 2011; 159(2):109-14
14) Xu JX, Yang M, Deng KJ, Zhou H*. Antioxidant Activities of Dracocephalum Tanguticum Maxim Extract and Its Up-regulation on the Expression of Neurotrophic Factors in a Rat Model of Permanent Focal Cerebral Ischemia. Am J Chin Med. 2011; 39(1): 65-81
15) Wang X, Xu J, Yang M, Zhou H*. Chloroform extract of Tibetan herbal medicine Dracocephalum tanguticum Maxim inhibits proliferation of T98G glioblastomas cells by modulating caspase-3 cleavage and expression of Bax and p21. J Med Plant Res. 2011; 5(25): 6024–6031
16) Wang X, Wang Y, Yang M, Zhou H*. A newly identified epithelial cell adhesion molecule (EpCAM) from grass carp (Ctenopharyngodon idellus): cloning, tissue distribution and lipopolysaccharide-induced expression in head kidney lymphocytes. Fish and Shellfish Immunol. 2010; 29(6):998-1002
17) Yang M, Wang Y, Wang X, Chen C, Zhou H*. Characterization of grass carp (Ctenopharyngodon idellus) Foxp1a/1b/2: evidence for their involvement in the activation of peripheral blood lymphocyte subpopulations. Fish Shellfish Immunol. 2010; 28:289-295
18) Song C, Wang X, Zhou H*. Molecular cloning of activin type I and type II receptors and differential regulation of their expression by activin in grass carp pituitary cells. Gen Comp Endocrinol. 2010; 166:211-216.
19) Chen C, Song C, Wang X, Zhou H*. Molecular cloning, characterization and tissue distribution of six splice variants of activin type IIA receptor (ActRIIA) from grass carp (Ctenopharyngodon idellus). Genes & Genetic Systems. 2009; 84:335-344.
20) Zhou H, Fu G, Yu H, Peng C. Transforming growth factor-beta inhibits aromatase gene transcription in human trophoblast cells via the Smad2 signaling pathway. Reprod Biol Endocrin. 2009; 7:146-155.
21) Zhou L, Yang M, Zhou H, Zhang J, Li K, Xiang Y, Wang N, Tian Y, Yu X. Novel Reticular Cyclen-Based Polymer as Gene Vector in DNA Transfection. Chem Biol Drug Des. 2009; 73(2): 216-224.
22) Wang Z, Yang M, Wang X, Zhou H*. High-level expression, purification, and characterization of the recombinant grass carp pituitary adenylate cyclase-activating polypeptide (PACAP). Biosci. Biotechnol. Biochem. 2008; 72(6):1550-7.
23) Yang M and Zhou H*. Grass carp transforming growth factor-?1 (TGF-?1): Molecular cloning, tissue distribution and immunobiological activity in teleost peripheral blood lymphocytes. Mol Immunol. 2008; 45(6): 1792–1798.
24) Sze KH, Zhou H, Yang Y, He M, Jiang Y, Wong AO. Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) as a Growth Hormone (GH)-Releasing Factor in Grass Carp: II. Solution Structure of a Brain-Specific PACAP by Nuclear Magnetic Resonance Spectroscopy and Functional Studies on GH Release and Gene Expression. Endocrinology. 2007; 148(10):5042-59.
25) Xu G, Zhou H, Wang Q, Auersperg N,Peng C. Activin receptor-like kinase 7 induces apoptosis through up-regulation of Bax and down-regulation of Xiap in normal and malignant ovarian epithelial cell lines. Mol Cancer Res. 2006; 4(4):235-46.
26) Wang AO, Zhou H, Jiang Y, Ko WK. Feedback regulation of growth hormone synthesis and secretion in fish and the emerging concept of intrapituitary feedback loop. Comp Biochem Physiol A Mol Integr Physiol. 2006; 144:284-305.
27) Zhou H, Jiang Y, Ko WK, Li W, Wong AO. Paracrine Regulation of Growth Hormone Gene Expression by Gonadotropin Release in Grass Carp Pituitary Cells: Functional Implications, Molecular Mechanisms, and Signal Transduction. Journal of Mol Endocrinol. 2005; 34(2): 415-432.
28) Wong AO, Li W, Leung CY, Huo L, Zhou H. Pituitary adenylate cyclase-activating polypeptide (PACAP) as a growth hormone (GH)-releasing factor in grass carp. I. Functional coupling of cyclic adenosine 3',5'-monophosphate and Ca2+/calmodulin-dependent signaling pathways in PACAP-induced GH secretion and GH gene expression in grass carp pituitary cells. Endocrinology. 2005; 146(12):5407-24.
29) Zhou H, Ko WK, Ho WK, Stojilkovic SS, Wong AO. Novel Aspects of Growth Hormone Autoregulation: Growth Hormone-Induced Growth Hormone Gene Expression in Grass Carp Pituitary Cells through Autocrine/Paracrine Mechanisms. Endocrinology 2004; 145(10): 4615-4628.
30) Zhou H, Wang X, Ko WK, Wong AO. Evidence for a Novel Intrapituitary Autocrine/Paracrine Feedback Loop Regulating Growth Hormone Synthesis and Secretion in Grass Carp Pituitary Cells by Functional Interactions between Gonadotrophs and Somatotrophs. Endocrinology 2004; 145(12):5548-5559.
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专业研究方向:
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专业名称 |
研究领域/方向 |
招生类别 |
071000生物学 |
01生物化学与分子生物学,04细胞生物学 |
硕士学术学位 |
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