医学院
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| 导师代码： |
21138
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| 导师姓名： |
马圣运
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| 性 别： |
男 |
| 特 称： |
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| 职 称： |
研究员
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| 学 位： |
理学博士学位
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| 属 性： |
专职 |
| 电子邮件： |
sma@uestc.edu.cn
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| 学术经历：
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2023.07-2024.01 美国拉霍亚免疫研究所 讲师
2022.03-2023.06 加州大学圣地亚哥分校 助理项目科学家
2017.03-2022.02 加州大学圣地亚哥分校 博士后
2016.05-2016.12 德国美因茨大学 博士后
2012.08-2016.02 德国美因茨大学 理学博士
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| 个人简介：
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马圣运，博士毕业于德国美因茨大学（Johannes Gutenberg-University Mainz），后相继在美国加州大学圣地亚哥分校（University of California, San Diego）做博士后和助理项目科学家、美国拉霍亚免疫研究所做讲师。2023入选电子科技大学百人计划青年项目。2024年初加入医学院，任特聘研究员，博士生导师。
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| 科研项目：
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免疫系统是一把强大的双刃剑。一方面，它武装起来对抗各种入侵的外来病原体。另一方面，如果不加以控制，它还会攻击生物体自身的组织，引起炎症和自身免疫性疾病，如过敏、哮喘、类风湿性关节炎、多发性硬化症和炎性肠病。凭借 RNA 生物学和粘膜免疫方面的专业知识，我们将利用独特的遗传和基因组工具来揭示免疫背后的新分子机制，为研发治疗相关疾病提供新的策略或者靶点。
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| 研究成果：
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1. Ma S*#, Yang Q, Chen N, Zheng A, Abbasi N, . . . Huang WJM. (2023). RNA binding protein DDX5 restricts RORgt+ Treg suppressor function to promote intestine inflammation. Science Advances, 9(5), eadd6165.
2. Ma S, Patel SA, Abe Y, Chen N, Patel PR, Cho BS, . . . Huang WJM. (2022). RORgt phosphorylation protects against T cell-mediated inflammation. Cell Reports, 38(11), 110520.
3. He L*, Ma S*, Ding Z, Huang Z, Zhang Y, Xi C, . . . Huang C. (2024). AURKB-dependent regulation of NFAT5 contributes to neuropathic pain. Advanced Science, 2302916
4. Ma S *#, Hernandez JE, & Huang WJM. (2022). Protocol to assess cell-intrinsic regulatory mechanisms using an ex vivo murine T cell polarization and co-culture system. STAR Protocol, 3(3), 101543.
5. Ma S, Long T, Huang WJM. Noncoding RNAs in inflammation and colorectal cancer. RNA Biology. 2020 Nov;17(11):1628-1635.
6. Ma S, Bai Y, Han N, Wang J, Weng X, Bian H, Zhu M. [Recent research progress of biogenesis and functions of miRNA*]. Yi Chuan. 2012 Apr;34(4):383-8. Chinese.
7. Hernandez JE, LIorente C, Ma S, Miyamoto KT, Sinha S, . . . Huang WJM. (2023). The arginine methyltransferase PRMT5 promotes mucosal defense in the intestine. Life Science Alliance, 6 (11).
8. Long T, Hernandez JE, Ma S, Steele S, Luo C, . . . Huang WJM. (2023). The long non-coding RNA MALAT1 regulates intestine host-microbe interactions and polyposis. Frontiers in Cell and Developmental Biology, 11 (2296-634X), 500.
9. Louis TL, Wong WH, Yao P, Kurd NS, Tysl T, Indralingam CS, Ma S,. . . Chang JT. (2023). Regulation of CD8 T Cell Differentiation by the RNA-Binding Protein DDX5. The Journal of Immunology, 219(6).
10. Zeng S, Rosati E, Saggau C, Messner B, Chu H, Duan Y, Hartmann P, Wang Y, Ma S, … Bernd Schnabl. (2023). Candida albicans-specific Th17 cell-mediated response contributes to alcohol-associated liver disease, Cell Host Microbe, 31(3): 389-404
11. Kanbar JN, Ma S, Kim ES, Kurd NS, Tsai MS, Tysl T, . . . Chang JT. (2022). The long noncoding RNA Malat1 regulates CD8+ T cell differentiation by mediating epigenetic repression. Journal of Experimental Medicine, 219(6).
12. Long T, Abbasi N, Hernandez JE, Li Y, Sayed IM, Ma S, . . . Huang WJM. (2021). RNA binding protein DDX5 directs tuft cell specification and function to regulate microbial repertoire and disease susceptibility in the intestine. Gut, 71(9), 1790-1802.
13. Shen Y, Ding Z, Ma S, Zou Y, Yang X, . . . Huang C. (2020). Targeting aurora kinase B alleviates spinal microgliosis and neuropathic pain in a rat model of peripheral nerve injury. Journal of Neurochemistry, 152(1), 72-91.
14. Shen Y, Ding Z, Ma S, Ding Z, Zhang Y, . . . Huang C. (2019). SETD7 mediates spinal microgliosis and neuropathic pain in a rat model of peripheral nerve injury. Brain, Behavior, and Immunity, 82, 382-395.
15. Li X, Guo F, Ma S, Zhu M, Pan W, & Bian H. (2019). Regulation of flowering time via miR172-mediated APETALA2-like expression in ornamental gloxinia (Sinningia speciosa). Journal of Zhejiang University-science B, 20(4), 322-331.
16. Marquardt JU, Fischer K, Baus K, Kashyap A, Ma S, Krupp M, . . . Strand S. (2013). Sirtuin-6-dependent genetic and epigenetic alterations are associated with poor clinical outcome in hepatocellular carcinoma patients. Hepatology, 58(3), 1054-1064.
17. Li X, Bian H, Song D, Ma S, Han N, Wang J, & Zhu M. (2013). Flowering time control in ornamental gloxinia (Sinningia speciosa) by manipulation of miR159 expression. Annals of botany, 111(5), 791-799.
18. Bian H, Xie Y, Guo F, Han N, Ma S, Zeng Z, . . . Zhu M. (2012). Distinctive expression patterns and roles of the miRNA393/TIR1 homolog module in regulating flag leaf inclination and primary and crown root growth in rice (Oryza sativa). The New phytologist, 196(1), 149-161.
19. Shaobin G, Wu Y, Li K, Li S, Ma S, Wang Q, & Wang R. (2010). A pilot study of the effect of audible sound on the growth of Escherichia coli. Colloids Surf B Biointerfaces, 78(2), 367-371.
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| 专业研究方向：
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| 专业名称 |
研究方向 |
招生类别 |
| 107200生物医学工程 |
01医学基础研究 |
博士学术学位 |
| 071000生物学 |
01生物化学与分子生物学 |
硕士学术学位 |
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