导师个人信息 - 电子科大研招网

医学院

导师代码：	11844
导师姓名：	李小平
性别：	男
特称：
职称：	研究员
学位：	医学博士学位
属性：	专职
电子邮件：	lixiaoping0119@163.com

学术经历：

硕士期间主要从事高血压流行病学和临床课题，参与过西北五省高血压流行病学调查的课题；博士期间主要从事病毒性心肌炎、心肌病中细胞凋亡机制的研究；在国外博士联合培养期间主要从事感染性心肌病（脓毒症所致心功能障碍）中有关信号通路的研究；博士后期间主要是从事多种心肌病（扩心病、肥心病、ARVC、限制性心肌病等）临床特征及预后危险因素的研究，并在这些心肌病的家系和散发病例中进行遗传学研究。目前，主要偏向于心肌病（扩心病和肥心病）、心律失常的临床预后和遗传学研究。近10年来一直致力于心肌病和心律失常临床预后及遗传学研究，2015年获省青年科技奖、2015年以第一完成人分别获得四川省科技进步奖三等奖、成都市科技进步奖二等奖、2016年入选中国医师协会心血管分会“未来之星”培养项目和四川省“****”、2016年获得国家留学基金委西部地区人才培养特别项目、2020年入选四川省卫生健康委员会学术技术带头人、2021年入选四川省学术和技术带头人。同时，近年来先后担任中华医学会心电生理与起搏分会青年委员、省医学会心电生理与起搏专委会青年委员会副主任委员、国家自然科学基金委医学部一审专家、四川省青科联联合会常务理事等。

个人简介：

祖籍及出生于湖南衡阳市耒阳市新市镇，2001-2004年硕士毕业于兰州医学院，2006年-2009年博士毕业于复旦大学，师从陈灏珠院士；2007年-2008年获首届“国家建设高水平大学”全额奖学金在加拿大西安大略大学维多利亚医院公派留学1年，2011-2014年在中国医学科学院阜外心血管病医院心律失常中心从事博士后工作，，师从华伟教授；2017年于美国加州大学旧金山分校留学半年。自2004年开始在医学院或医科大学附属医院心内科工作，主要亚专业为起搏电生理，主要从事临床心脏电生理工作，多次在国内外知名医学中心学习，尤其是复杂的持续性房颤的射频消融治疗，并在省内外率先进行全景式左右心房低电压区域基质改良来提高持续性房颤的成功率，这一改良后的术式也得到了国内房颤领域多个权威专家的认可，并获得首届广东钟南山医学基金会房颤导管消融临床研究项目的资助。

科研项目：

近10年来，主持或参与科研课题20余项，其中作为负责人主持国家自然科学基金3项（1个青年基金和2个面上项目）、四川省科技厅重点研发项目1项等科研项目、中央高校基本科研业务费项目1项等。以第一申请人获得专利3项，申报PCT1项。

研究成果：

发表学术论文70余篇，以第一作者或通讯作者（包括并列）发表SCI论文30余篇，包括1篇为通讯作者的中科院双1区论文（该领域Top杂志），中科院2区杂志9篇（ #为第一作者或并列第一作者， *为通讯作者）： 1. Huang J, Luo R, Zheng C, Cao X, Zhu Y, He T, Liu M, Yang Z, Wu X, Li X*. Integrative Analyses Identify Potential Key Genes and Calcium-Signaling Pathway in Familial Atrioventricular Nodal Reentrant Tachycardia Using Whole-Exome Sequencing. Front Cardiovasc Med. 2022;9:910826. 2. Hong Y, Su WW, Li X*. Risk factors of sudden cardiac death in hypertrophic cardiomyopathy. Curr Opin Cardiol. 2022;37(1):15-21. 3. Luo K, Zheng C, Luo R, Cao X, Sun H, Ma H, Huang J, Yang X, Wu X, Li X*. Identification and functional characterization of BICD2 as a candidate disease gene in an consanguineous family with dilated cardiomyopathy. BMC Med Genomics. 2022;15(1):189. 4. Ma H, Cao X, Zhang J, Zhou Y, Luo R, He T, Tao J, Li X*. Systemic Lupus Erythematosus Complicated with Hypertrophic Cardiomyopathy: A Case Report and Literature Review. Case Rep Cardiol. 2021:6633085. 5. Liu S, Hong Y, Huang K, Li X*. Multiple left ventricular myxomas combined with severe rheumatic valvular lesions: A case report. World J Clin Cases. 2021 Jul 16;9(20):5535-5539. 6. Li X#, Lai L, Luo R, Yang H, Ma H, Yang Z, Zhao S, Su W, Hua W. The Clinical Prognosis of Presence and Location of Late Gadolinium Enhancement by Cardiac Magnetic Resonance Imaging in Patients with Hypertrophic Cardiomyopathy: a Single-Center Cohort Study. J Cardiovasc Transl Res. 2021 Feb 24. 7. Chen XP, Yan C, Luo R, Zhu Y, Qian M, Liu X, Liu M, Ikeda T, Li X*. Clinical report of 8 cases of familial atrioventricular nodal reentrant tachycardia from China. Kardiol Pol. 2021 Jan 7. 8. Zhang N, Hua W, Li X*, et al. Echocardiographic Predictors of All-Cause Mortality in Patients with Hypertrophic Cardiomyopathy following Pacemaker Implantation [J]. Cardiol Res Pract. 2020;2020:2923767. 9. Yan, C. , Luo, R. , Li, F. , Liu, M. , Li, J,Li, X*. The epidemiological status, environmental and genetic factors in the etiology of Keshan disease[J]. Cardiovascular Endocrinology & Metabolism, 2020, Publish Ahead of Print. 10. Dai X, Luo R, Chen Y, Zheng C, Tang Y, Zhang H, Su Y, He T, Li X*. A Novel EMD Mutation Identified by Whole-Exome Sequencing in Twins with Emery-Dreifuss Muscular Dystrophy. Case Rep Genet. 2020 Aug 24;2020:2071738. 11. Luo R, Zheng C, Yang H, Chen X, Jiang P, Wu X, Yang Z, Shen X, Li X*. Identification of potential candidate genes and pathways in atrioventricular nodal reentry tachycardia by whole-exome sequencing. Clin Transl Med. 2020;10(1):238-257. 12. Dai X, Zheng C, Chen X, Tang Y, Zhang H, Yan C, Ma H, Li X*. Targeted next-generation sequencing identified a known EMD mutation in a Chinese patient with Emery-Dreifuss muscular dystrophy. Hum Genome Var. 2019 Sep 3;6:42 13. Chen X, Peng H, Zheng C, Zhang H, Yan C, Ma H, Dai X, Li X*. Two pedigrees with arrhythmogenic right ventricular cardiomyopathy linked with R49H and F531C mutation in DSG2. Hum Genome Var. 2019 Aug 21;6:38. 14. Shi Y, Li Y, Wang Y, Zhuang J, Wang H, Hu M, Mo X, Yue S, Chen Y, Fan X, Chen J, Cai W, Zhu X, Wan Y, Zhong Y, Ye X, Li F, Zhou Z, Dai G, Luo R, Ocorr K, Jiang Z, Li X*, et al. The Functional Polymorphism R129W in the BVES Gene Is Associated with Sporadic Tetralogy of Fallot in the Han Chinese Population. Genet Test Mol Biomarkers. 2019 Sep;23(9):601-609. 15. Chen C, Liu J, Liu Z, He X, Yuan X, Ouyang X, Wang L, Li X*. Electrocardiogram signs of right ventricular hypertrophy may help identify pulmonary hypertension in patients with dilated cardiomyopathy. Int J Cardiol Heart Vasc. 2018 Dec 27;22:61-66. 16. Luo R, Chen X, Ma H, Yao C, Liu M, Tao J, Li X*. Myocardial caspase-3 and NF-κB activation promotes calpain-induced septic apoptosis: The role of Akt/eNOS/NO pathway. Life Sci. 2019 Apr 1;222:195-202. 17. Lai L, Jiang R, Fang W, Yan C, Tang Y, Hua W, Fu M, Li X*, Luo R*. Prognostic impact of right bundle branch block in hospitalized patients with idiopathic dilated cardiomyopathy: a single-center cohort study. J Int Med Res. 2020 Jan;48(1):300060518801478. 18. Fang W, Luo R, Tang Y, Hua W, Fu M, Chen W, Lai L, Li X*. The Prognostic Factors of Alcoholic Cardiomyopathy: A single-center cohort study. Medicine (Baltimore). 2018 Aug;97(31):e11744. 19. Li X#, Luo R, Fang W, Xu X, Niu G, Xu Y, Fu M, Hua W, Wu X. Effects of ventricular conduction block patterns on mortality in hospitalized patients with dilated cardiomyopathy: a single-center cohort study. BMC Cardiovasc Disord. 2016 Jun 13;16:136. 20. Li X#, Luo R, Fang W, Xu X, Niu G, Xu Y, Fu M, Hua W, Wu X. Effects of ventricular conduction block patterns on mortality in hospitalized patients with dilated cardiomyopathy: a single-center cohort study. BMC Cardiovasc Disord. 2016 Jun 13;16:136. 21. Li X#, Cai C, Luo R, Jiang R, Zeng J, Tang Y, Chen Y, He T, Hua W. The usefulness of age and gender to predict all-cause mortality in patients with dilated cardiomyopathy: a single-center cohort study. Clinical Interventions in Aging. 2015. 10:1479-86. 22. Li X#, Luo R, Chan CP, Zhang S, Hua W. History of diabetes mellitus was not a predictor of all-cause mortality in dilated cardiomyopathy-Reply to the letter from Sahin O et al. Int J Cardio. 2015, 179: 40-41. 23. Li X#, Chen C, Gan F, Wang Y, Ding L, Hua W. Plasma NT pro-BNP, hs-CRP and big-ET levels at admission as prognostic markers of survival in hospitalized patients with dilated cardiomyopathy: a single-center cohort study. BMC Cardiovasc Disord. 24. Li X#, Luo R, Jiang R, Kong H, Tang Y, Shu Y, Hua W. The prognostic use of serum concentrations of cardiac troponin-I, CK-MB and myoglobin in patients with idiopathic dilated cardiomyopathy. Heart Lung.2014, 43(3):219-224. 25. Li X#, Luo R, Chen R, Song L, Zhang S, Hua W, Chen H. Cleavage of IκBα by calpain induces myocardial NF-κB activation, TNF-α expression, and cardiac dysfunction in septic mice. Am J Physiol Heart Circ Physiol. 2014, 306(6):H833-843. 26. Li X#, Luo R, Chan CP, Wu X, Zhang S, Hua W. The clinical correlates and prognostic impact of QRS prolongation in patients with dilated cardiomyopathy: A single-center cohort study. Int J Cardiol. 2014, 172(3):e475-477. 27. Li X#, Jiang R, Kong H, Shu Y, Li Q, Hua W. Fasting blood glucose at admission and survival in patients with dilated cardiomyopathy: a single-center cohort study. Experimental and Clinical Endocrinology & Diabetes. 2014, 122: 457-462. 28. Li X#, Luo R, Gu H, Wu X, Hua W. Cardiac troponin T (TNNT2) mutations in Chinese dilated cardiomyopathy patients. Biomed Res Int. 2014, 907360 29. Li X#, Yang X, Wang Y, Ding L, Wang J, Hua W. The prevalence and prognostic effects of subclinical thyroid dysfunction in dilated cardiomyopathy patients: a single-center cohort study. J Card Fail. 2014, 20(7):506-512. 30. Luo R#, Li X#, Wang Y, Li Y, Deng Y, Wan Y, Jiang Z, Hua W, Wu X. The Influence of Angiotensin Converting Enzyme and Angiotensinogen Gene Polymorphisms on Hypertrophic cardiomyopathy. PLoS One. 2013, 8(10), e77030. 31. Luo R#, Li X#, Fan X, Yuan W, Wu X. Association of Tumor Necrosis Factor-α gene G-308A polymorphism with dilated cardiomyopathy: a meta-analysis. DNA Cell Biol. 2013, 32 (3): 130-137. 32. Li X#, Chan CP, Hua W, Ding L, Wang J, Zhang S, Li S, Zhang Y. Prognostic impact of late gadolinium enhancement by cardiac magnetic resonance imaging in patients with non-ischaemic dilated cardiomyopathy. Int J Cardiol.2013, 168(5), 4979-4980. 33. Li X#, Luo R, Mo X, Jiang R, Kong H, Hua W, Wu X. Polymorphism of ZBTB17 gene is associated with idiopathic dilated cardiomyopathy: a case control study in a Han Chinese population. Eur J Med Res. 2013, 18:10. 34. Li X#, Luo R, Jiang R, Meng X, Wu X, Zhang S, Hua W. The role of the Hsp90/Akt pathway in myocardial calpain-induced caspase-3 activation and apoptosis during sepsis. BMC Cardiovasc Disord. 2013, 13:8. 35. Li X#, Wang H, Luo R, Gu H, Zhang C, Zhang Y, Hui R, Wu X, Hua W. TNNT2 gene polymorphisms are associated with susceptibility to idiopathic dilated cardiomyopathy in a Han Chinese population. Biomed Res Int. 2013, 201372. 36. Luo R#, Li X#, Jiang R, Gao X, Lü Z, Hua W. Serum concentrations of resistin and adiponectin and their relationship to insulin resistance in subjects with impaired glucose tolerance. J Int Med Res. 2012;40(2):621-30. 37. Li X#, Luo R, Jiang R, Chen R, Hua W. Human leukocyte antigen-DQB1 gene polymorphisms are associated with dilated cardiomyopathy: A systematic review and meta-analysis. Heart Lung. 2012, 41(4): 360-367. 38. Deng J, Luo R, Li X*. HLA-DRB1 gene polymorphism is associated with idiopathic dilated cardiomyopathy: a meta-analysis. J Cardiovasc Med (Hagerstown). 2011 Sep;12(9):648-52. 39. Hu H＃, Li X＃, Li Y, Wang L, Mehta S, Feng Q, Chen R, Peng T. Calpain-1 induces apoptosis in pulmonary microvascular endothelial cells under septic conditions. Microvasc Res. 2009 Jun;78(1):33-9. 40. Li X＃, Li Y, Shan L, Shen E, Chen R, Peng T. Over-expression of calpastatin inhibits calpain activation and attenuates myocardial dysfunction during endotoxaemia. Cardiovasc Res. 2009 Jul 1;83(1):72-9. 41. 朱云才, 张鹏, 贺涛, 陈旸, 陈宇, 刘明江, 唐艺加, 李小平. 拖带标测融合高密度标测成功治疗复杂房性心动过速一例. 中国心脏起搏与心电生理杂志. 2022, 36(02):173-175. 42. 朱云才, 陈旸, 李小平. 离子通道及自主神经系统与房室结折返性心动过速关系的研究进展. 实用心电学杂志. 2021, 30(01):8-12. 43. 朱云才, 李小平. 心房颤动的遗传学研究进展. 岭南心血管病杂志. 2021, 27(02):232-235. 44. 张潇文, 郑欣, 李小平. Emery-Dreifuss肌营养不良遗传学研究进展. 中风与神经疾病杂志. 2021, 38(12): 1144-1146. 45. 洪英，刘胜中，罗蓉，李小平.心脏黏液瘤的遗传学研究进展. 中国分子心脏病学杂志. 2020, 77-80. 46. 文琴，罗蓉，刘明江，周咏梅，李小平. 心力衰竭临床预后相关模型的进展. 临床心血管病杂志. 2020,36(6):497-501. 47. 李小平, 颜超, 罗蓉, 贺涛, 刘明江, 陶剑虹, 华伟. 房室结折返性心动过速3个家系的报道. 临床心血管病杂志. 2020, 36(05):471-475. 48. 马慧慧, 周咏梅, 罗蓉, 李小平. 致心律失常性右室心肌病的临床特征及预后因素. 心血管病学进展. 2019, 40(02): 272-276. 49. 马慧慧，李小平. 致心律失常性右室心肌病的遗传学研究进展.临床心血管病杂志. 2019, 35（2）：104-108. 50. 徐理飞,叶兴雨,罗蓉,李小平.克山病的遗传学进展. 心血管病学进展. 2018, 39(04): 671-673. 51. 颜超，罗蓉，张红梅，李小平等. 左室心肌致密化不全患者的临床特点及预后因素分析. 临床心血管病杂志. 2018, 34 (09): 903-908. 52. 颜超, 罗蓉, 张红梅, 李小平等. 92例克山病患者的临床特点及预后影响因素分析. 临床心血管病杂志. 2018,34 (08):773-777. 53. 方位，颜超，罗蓉，唐义斌，张红梅，陶剑虹，华伟，李小平.原发性扩张型心肌病和酒精型心肌病患者临床与预后对比研究. 临床心血管病杂志. 2018, 34(3): 226-231. 54. 方位, 颜超, 林艳, 罗蓉, 李小平. 19例心肌淀粉样变性患者的临床特点及预后分析. 临床心血管病杂志. 2017, 33(2): 115-118. 55. 颜超, 方位, 李小平, 蔡卫.克山病病情现状和病因学进展. 心血管病学进展. 2017, 38 (2): 225-229. 56. 方位，李小平. 家族性扩张型心肌病常见突变的研究进展. 医学综述. 2016, 22 (18): 3537-3540. 57. 方位, 罗蓉,李小平. 核纤层蛋白基因相关性心肌病. 心血管病学进展. 2016, 37(6): 651-655.

专业研究方向：